Suppressed induction of 2-5AS in cells with HTLV-I is not associated with the fluctuation of IFN-receptor, IFN-regulatory factors (IRF-1 and IRF-2) or STAT-1 alpha

被引:1
作者
Yokosawa, N
Indoh, T
Kubota, T
Yashiki, T
Fujii, N
机构
[1] SAPPORO MED UNIV,SCH MED,DEPT MICROBIOL,CHUO KU,SAPPORO,HOKKAIDO 060,JAPAN
[2] HOKKAIDO UNIV,COLL MED TECHNOL,LAB TECHNOL,SAPPORO,HOKKAIDO 060,JAPAN
关键词
2-5AS; interferon; IRF; HTLV-I; persistent infection; STAT-1; alpha;
D O I
10.1111/j.1348-0421.1997.tb01173.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Some viruses seem to be capable of suppressing interferon (IFN)-induced 2', 5'-oligoadenylate synthetase (2-5AS) induction. Cells infected with human T-lymphotropic virus type-I (HTLV-I) show different natures for the constitutive production of IFN-gamma or sensitivity to IFN, Poor induction of 2-5AS was found in IFN-gamma producer cells carrying HTLV-I (MT-1, MT-2 and SMT-1). On the other hand, in non- or low-producing cell lines of IFN-gamma such as HUT102 and OKM-2, significant activity of 2-5AS was induced by treatment with IFN-alpha. A satisfactory level of IFN receptor was detectable in SMT-1 cells in spite of the poor induction of 2-5AS, There were no differences in either the interferon regulatory factor-2 (IRF-2) mRNA transcript or the level of STAT-1 alpha between SMT-1 and HUT102 cells, However, the transcription of IRF-1 mRNA was slightly reduced in SMT-1 cells as compared with that of HUT102 cells.
引用
收藏
页码:63 / 66
页数:4
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