Tolerability of Bowel Preparation and Colonoscopy in IBD Patients: Results From a Prospective, Single-Center, Case-Control Study

被引：3

作者：

Bezzio, Cristina ^{[1
]}

Schettino, Mario ^{[1
]}

Manes, Gianpiero ^{[1
]}

Andreozzi, Paolo ^{[2
]}

Arena, Ilaria ^{[1
]}

Della Corte, Cristina ^{[1
]}

Costetti, Martina ^{[3
,4
]}

Devani, Massimo ^{[1
]}

Omazzi, Barbara Federica ^{[1
]}

Saibeni, Simone ^{[1
]}

机构：

[1] ASST Rhodense, Rho Hosp, Gastroenterol Unit, Corso Europa 250, I-120017 Rho, MI, Italy

[2] Marcianise Hosp, ASL Caserta, Gastroenterol Unit, Marcianise, Italy

[3] San Matteo Hosp, Dept Internal Med, Pavia, Italy

[4] Univ Pavia, Pavia, Italy

来源：

CROHNS & COLITIS 360 | 2020年 / 2卷 / 04期

关键词：

Crohn's disease; ulcerative colitis; endoscopy; sedation; bowel preparation; UNSEDATED COLONOSCOPY; CROHNS-DISEASE; ENDOSCOPY; EFFICACY; VALIDATION;

D O I：

10.1093/crocol/otaa077

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Endoscopy plays a fundamental role in the management of patients with inflammatory bowel disease (IBD). The aim of this study was to prospectively evaluate the tolerability and efficacy of bowel preparation and colonoscopy in ulcerative colitis (UC) and Crohn's disease (CD) patients compared to subjects participating in a colorectal cancer population screening program. Methods: Consecutive enrolment of CD and UC patients and screening subjects (SS) undergoing colonoscopy. Bowel preparation was done by split dose of 2 L PEG-ELS + simethicone. We recorded endoscopic, clinical, and demographic features; cleanliness rating using the Boston Bowel Preparation Scale (BBPS); and sedation doses. Bowel-preparation tolerability, discomfort, and pain during colonoscopy were assessed using a Visual Analogue Scale from 0 to 100 mm. Results: Sixty-three UC (mean age 49.9 +/- 14.9 years), 63 CD (mean age 44.0 +/- 14.0 years), and 63 SS (mean age 59.9 +/- 6.3 years) patients were enrolled. Bowel preparation was similarly tolerated in UC, CD, and SS (P = 0.397). A complete colonoscopy was similarly performed in UC (59/63, 93.7%), CD (58/63, 92.1%), and SS (60/63, 95.2%) (P = 0.364). The BBPS did not show significant differences between UC (6.2 +/- 1.6), CD (6.1 +/- 1.3), and SS (6.2 +/- 1.4) (P = 0.824). The need to increase sedation doses was significantly higher in CD (24/63, 38.1%) and UC (16/63, 25.4%) than in SS (4/63, 6.3%) (P < 0.0001). Conclusions: Bowel preparation is equally tolerated and efficacious in IBD patients and in healthy SS. In IBD, higher sedation doses are needed to guarantee an equally tolerated colonoscopy. Lay Summary Bowel preparation, done by split dose of 2 L, was equally tolerated and efficacious in Crohn's disease and ulcerative colitis patients and in healthy subjects undergoing colonoscopy. In IBD patients, higher sedation doses are needed to guarantee an equally tolerated colonoscopy.

引用

页码：1 / 6

页数：6

共 24 条

[1] European evidence based consensus for endoscopy in inflammatory bowel disease [J].

Annese, Vito ;

Daperno, Marco ;

Rutter, Matthew D. ;

Amiot, Aurelien ;

Bossuyt, Peter ;

East, James ;

Ferrante, Marc ;

Goetz, Martin ;

Katsanos, Konstantinos H. ;

Kiesslich, Ralf ;

Ordas, Ingrid ;

Repici, Alessandro ;

Rosa, Bruno ;

Sebastian, Shaji ;

Kucharzik, Torsten ;

Eliakim, Rami .

JOURNAL OF CROHNS & COLITIS, 2013, 7 (12) :982-1018

[2] Mucosal Healing Predicts Sustained Clinical Remission in Patients With Early-Stage Crohn's Disease [J].

Baert, Filip ;

Moortgat, Liesbeth ;

Van Assche, Gert ;

Caenepeel, Philip ;

Vergauwe, Philippe ;

De Vos, Martine ;

Stokkers, Pieter ;

Hommes, Daniel ;

Rutgeerts, Paul ;

Vermeire, Severine ;

D'Haens, Geert .

GASTROENTEROLOGY, 2010, 138 (02) :463-468

[3]

Bessissow T, 2013, J CROHNS COLITIS, V7, P580

[4] Endoscopy for patients affected by inflammatory bowel disease: bowel preparation and sedation [J].

Bezzio, Cristina ;

Andreozzi, Paolo ;

Casini, Valentina ;

Manes, Gianpiero ;

Saibeni, Simone .

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2018, 12 (02) :119-124

[5] Efficacy, Tolerability, and Safety of Low-Volume Bowel Preparations for Patients with Inflammatory Bowel Diseases: The French Multicentre CLEAN Study [J].

Briot, C. ;

Faure, P. ;

Parmentier, A. L. ;

Nachury, M. ;

Trang, C. ;

Viennot, S. ;

Altwegg, R. ;

Bulois, P. ;

Thomassin, L. ;

Serrero, M. ;

Ah-Soune, P. ;

Gilletta, C. ;

Plastaras, L. ;

Simon, M. ;

Dray, X. ;

Caillo, L. ;

Del Tedesco, E. ;

Abitbol, V. ;

Zallot, C. ;

Degand, T. ;

Rossi, V. ;

Bonnaud, G. ;

Colin, D. ;

Morel, B. ;

Winkfield, B. ;

Danset, J. B. ;

Filippi, J. ;

Amiot, A. ;

Attar, A. ;

Levy, J. ;

Peyrin-Biroulet, L. ;

Vuitton, L. ;

Boureille, Arnaud ;

Blain, Antoine ;

Gay, Claire ;

Koch, Stephane ;

Ambregna, Sylvain ;

Vaurie, Fanny ;

Francois, Stephanie ;

Martin, Berenger ;

Agouzal, Khadija ;

Boivineau, Lucile ;

Branche, Julien ;

Gerard, Romain ;

Benezech, Alban ;

Aider, Belinda ;

Rouillon, Clea ;

Perrod, Guillaume ;

De Montigny, Stephanie ;

Aygalenq, Philippe .

JOURNAL OF CROHNS & COLITIS, 2019, 13 (09) :1121-1130

[6] Comparative Acceptability and Perceived Clinical Utility of Monitoring Tools: A Nationwide Survey of Patients with Inflammatory Bowel Disease [J].

Buisson, Anthony ;

Gonzalez, Florent ;

Poullenot, Florian ;

Nancey, Stephane ;

Sollellis, Elisa ;

Fumery, Mathurin ;

Pariente, Benjamin ;

Flamant, Mathurin ;

Trang-Poisson, Caroline ;

Bonnaud, Guillaume ;

Mathieu, Stephane ;

Thevenin, Alain ;

Duruy, Marc ;

Filippi, Jerome ;

L'hopital, Francois ;

Luneau, Fabrice ;

Michalet, Veronique ;

Genes, Julien ;

Achim, Anca ;

Cruzille, Emmanuelle ;

Bommelaer, Gilles ;

Laharie, David ;

Peyrin-Biroulet, Laurent ;

Pereira, Bruno ;

Nachury, Maria ;

Bouguen, Guillaume .

INFLAMMATORY BOWEL DISEASES, 2017, 23 (08) :425-433

[7] A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis [J].

D'Haens, Geert ;

Sandborn, William J. ;

Feagan, Brian G. ;

Geboes, Karel ;

Hanauer, Stephen B. ;

Irvine, E. Jan ;

Lemann, Marc ;

Marteau, Philippe ;

Rutgeerts, Paul ;

Scholmerich, Jurgen ;

Sutherland, Lloyd R. .

GASTROENTEROLOGY, 2007, 132 (02) :763-786

[8] Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD [J].

Daperno, M ;

D'Haens, G ;

Van Assche, G ;

Baert, F ;

Bulois, P ;

Maunoury, V ;

Sostegni, R ;

Rocca, R ;

Pera, A ;

Gevers, A ;

Mary, JY ;

Colombel, JF ;

Rutgeerts, P .

GASTROINTESTINAL ENDOSCOPY, 2004, 60 (04) :505-512

[9] Patients' perception of colonoscopy: patients with inflammatory bowel disease and irritable bowel syndrome experience the largest burden [J].

Denters, Maaike J. ;

Schreuder, Marthe ;

Depla, Annekatrien C. T. M. ;

Mallant-Hent, Rosalie C. ;

van Kouwen, Mariette C. A. ;

Deutekom, Marije ;

Bossuyt, Patrick M. ;

Fockens, Paul ;

Dekker, Evelien .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2013, 25 (08) :964-972

[10] Predicting inadequate bowel preparation for colonoscopy in participants receiving split-dose bowel preparation: development and validation of a prediction score [J].

Dik, Vincent K. ;

Moons, Leon M. G. ;

Huyuk, Melek ;

van der Schaar, Peter ;

Cappel, Wouter H. de Vos Tot Nederveen ;

ter Borg, Pieter C. J. ;

Meijssen, Maarten A. C. ;

Ouwendijk, Rob J. T. H. ;

Le Fevre, Doris M. ;

Stouten, Merijn ;

van der Galien, Onno ;

Hiemstra, Theo J. ;

Monkelbaan, Jan F. ;

van Oijen, Martijn G. H. ;

Siersema, Peter D. .

GASTROINTESTINAL ENDOSCOPY, 2015, 81 (03) :665-672

← 1 2 3 →