Optimization of targeted therapies to inhibit smooth muscle cell invasion in vitro

被引：0

作者：

Kennedy, CE ^{[1
]}

Massia, SP ^{[1
]}

机构：

[1] Arizona State Univ, Harrington Dept Bioengn, Lab Cellular & Biomat Interact, Tempe, AZ 85287 USA

来源：

PROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4: A NEW BEGINNING FOR HUMAN HEALTH | 2003年 / 25卷

关键词：

hyperplasia; smooth muscle cells; invasion; migration; integrin; peptide;

D O I：

10.1109/IEMBS.2003.1279470

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vascular smooth muscle cell (VSMC) proliferation and migration has been correlated with intimal hyperplasia (111) after vascular interventions such as angioplasty, stenting, and vascular graft surgery. Therefore, therapies targeting inhibition of VSMC migration may lead to higher patency rates in vascular grafts and reduced III in other vascular interventions. This study tested three targeted therapies and their combinations: hyperfunctional alpha(v)beta(3) integrin expression, cyclic-RGD release and tissue inhibitor of metalloprotease (TIMP)-1 release. It was found that a combination of 1.0 mM cyclic-RGD and 10 ng/mL TIMP-1 maximally inhibited smooth muscle cell invasion over individual or other combinations of treatments over 72 hours.

引用

页码：1215 / 1218

页数：4

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