Pancreatic cancer hidden in plain sight

被引:6
作者
Maitra, Anirban [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Sheikh Ahmed Ctr Pancreat Canc Res, Houston, TX 77005 USA
关键词
Cancer; Medical research; HLA CLASS-I; AUTOPHAGY;
D O I
10.1038/d41586-020-01103-3
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Pancreatic cancer does not respond to certain anticancer treatments that boost immune responses. A mechanism active in tumour cells that contributes to this evasion of immune targeting has been uncovered.
引用
收藏
页码:34 / 35
页数:2
相关论文
共 15 条
[11]   Fibroblasts in Pancreatic Ductal Adenocarcinoma: Biological Mechanisms and Therapeutic Targets [J].
Whittle, Martin C. ;
Hingorani, Sunil R. .
GASTROENTEROLOGY, 2019, 156 (07) :2085-2096
[12]   Putting the Immunologic Brakes on Cancer [J].
Wolchok, Jedd .
CELL, 2018, 175 (06) :1452-1454
[13]   Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I [J].
Yamamoto, Keisuke ;
Venida, Anthony ;
Yano, Julian ;
Biancur, Douglas E. ;
Kakiuchi, Miwako ;
Gupta, Suprit ;
Sohn, Albert S. W. ;
Mukhopadhyay, Subhadip ;
Lin, Elaine Y. ;
Parker, Seth J. ;
Banh, Robert S. ;
Paulo, Joao A. ;
Wen, Kwun Wah ;
Debnath, Jayanta ;
Kim, Grace E. ;
Mancias, Joseph D. ;
Fearon, Douglas T. ;
Perera, Rushika M. ;
Kimmelman, Alec C. .
NATURE, 2020, 581 (7806) :100-+
[14]   Pancreatic cancers require autophagy for tumor growth [J].
Yang, Shenghong ;
Wang, Xiaoxu ;
Contino, Gianmarco ;
Liesa, Marc ;
Sahin, Ergun ;
Ying, Haoqiang ;
Bause, Alexandra ;
Li, Yinghua ;
Stommel, Jayne M. ;
Dell'Antonio, Giacomo ;
Mautner, Josef ;
Tonon, Giovanni ;
Haigis, Marcia ;
Shirihai, Orian S. ;
Doglioni, Claudio ;
Bardeesy, Nabeel ;
Kimmelman, Alec C. .
GENES & DEVELOPMENT, 2011, 25 (07) :717-729
[15]   Recent insights into the biology of pancreatic cancer [J].
Yao, Wantong ;
Maitra, Anirban ;
Ying, Haoqiang .
EBIOMEDICINE, 2020, 53