Pancreatic cancer hidden in plain sight

被引：6

作者：

Maitra, Anirban ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Sheikh Ahmed Ctr Pancreat Canc Res, Houston, TX 77005 USA

来源：

NATURE | 2020年 / 581卷 / 7806期

关键词：

Cancer; Medical research; HLA CLASS-I; AUTOPHAGY;

D O I：

10.1038/d41586-020-01103-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pancreatic cancer does not respond to certain anticancer treatments that boost immune responses. A mechanism active in tumour cells that contributes to this evasion of immune targeting has been uncovered.

引用

页码：34 / 35

页数：2

共 15 条

[1] Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities [J].

Balachandran, Vinod P. ;

Beatty, Gregory L. ;

Dougan, Stephanie K. .

GASTROENTEROLOGY, 2019, 156 (07) :2056-2072

[2] Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer [J].

Bryant, Kirsten L. ;

Stalnecker, Clint A. ;

Zeitouni, Daniel ;

Klomp, Jennifer E. ;

Peng, Sen ;

Tikunov, Andrey P. ;

Gunda, Venugopal ;

Pierobon, Mariaelena ;

Waters, Andrew M. ;

George, Samuel D. ;

Tomar, Garima ;

Papke, Bjorn ;

Hobbs, G. Aaron ;

Yan, Liang ;

Hayes, Tikvah K. ;

Diehl, J. Nathaniel ;

Goode, Gennifer D. ;

Chaika, Nina V. ;

Wang, Yingxue ;

Zhang, Guo-Fang ;

Witkiewicz, Agnieszka K. ;

Knudsen, Erik S. ;

Petricoin, Emanuel F., III ;

Singh, Pankaj K. ;

Macdonald, Jeffrey M. ;

Tran, Nhan L. ;

Lyssiotis, Costas A. ;

Ying, Haoqiang ;

Kimmelman, Alec C. ;

Cox, Adrienne D. ;

Der, Channing J. .

NATURE MEDICINE, 2019, 25 (04) :628-+

[3] Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer [J].

Gettinger, Scott ;

Choi, Jungmin ;

Hastings, Katherine ;

Truini, Anna ;

Datar, Ila ;

Sowell, Ryan ;

Wurtz, Anna ;

Dong, Weilai ;

Cai, Guoping ;

Melnick, Mary Ann ;

Du, Victor Y. ;

Schlessinger, Joseph ;

Goldberg, Sarah B. ;

Chiang, Anne ;

Sanmamed, Miguel F. ;

Melero, Ignacio ;

Agorreta, Jackeline ;

Montuenga, Luis M. ;

Lifton, Richard ;

Ferrone, Soldano ;

Kavathas, Paula ;

Rimm, David L. ;

Kaech, Susan M. ;

Schalper, Kurt ;

Herbst, Roy S. ;

Politi, Katerina .

CANCER DISCOVERY, 2017, 7 (12) :1420-1435

[4] Genetic Mechanisms of Immune Evasion in Colorectal Cancer [J].

Grasso, Catherine S. ;

Giannakis, Marios ;

Wells, Daniel K. ;

Hamada, Tsuyoshi ;

Mu, Xinmeng Jasmine ;

Quist, Michael ;

Nowak, Jonathan A. ;

Nishihara, Reiko ;

Qian, Zhi Rong ;

Inamura, Kentaro ;

Morikawa, Teppei ;

Nosho, Katsuhiko ;

Abril-Rodriguez, Gabriel ;

Connolly, Charles ;

Escuin-Ordinas, Helena ;

Geybels, Milan S. ;

Grady, William M. ;

Hsu, Li ;

Hu-Lieskovan, Siwen ;

Huyghe, Jeroen R. ;

Kim, Yeon Joo ;

Krystofinski, Paige ;

Leiserson, Mark D. M. ;

Montoya, Dennis J. ;

Nadel, Brian B. ;

Pellegrini, Matteo ;

Pritchard, Colin C. ;

Puig-Saus, Cristina ;

Quist, Elleanor H. ;

Raphael, Ben J. ;

Salipante, Stephen J. ;

Shin, Daniel Sanghoon ;

Shinbrot, Eve ;

Shirts, Brian ;

Shukla, Sachet ;

Stanford, Janet L. ;

Sun, Wei ;

Tsoi, Jennifer ;

Upfill-Brown, Alexander ;

Wheeler, David A. ;

Wu, Catherine J. ;

Yu, Ming ;

Zaidi, Syed H. ;

Zaretsky, Jesse M. ;

Gabriel, Stacey B. ;

Lander, Eric S. ;

Garraway, Levi A. ;

Hudson, Thomas J. ;

Fuchs, Charles S. ;

Ribas, Antoni .

CANCER DISCOVERY, 2018, 8 (06) :730-749

[5] Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers [J].

Kinsey, Conan G. ;

Camolotto, Soledad A. ;

Boespflug, Amelie M. ;

Guillen, Katrin P. ;

Foth, Mona ;

Truong, Amanda ;

Schuman, Sophia S. ;

Shea, Jill E. ;

Seipp, Michael T. ;

Yap, Jeffrey T. ;

Burrell, Lance D. ;

Lum, David H. ;

Whisenant, Jonathan R. ;

Gilcrease, G. Weldon, III ;

Cavalieri, Courtney C. ;

Rehbein, Kaitrin M. ;

Cutler, Stephanie L. ;

Affolter, Kajsa E. ;

Welm, Alana L. ;

Welm, Bryan E. ;

Scaife, Courtney L. ;

Snyder, Eric L. ;

McMahon, Martin .

NATURE MEDICINE, 2019, 25 (04) :620-+

[6] Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma: A Phase 2 Randomized Clinical Trial [J].

O'Reilly, Eileen M. ;

Oh, Do-Youn ;

Dhani, Neesha ;

Renouf, Daniel J. ;

Lee, Myung Ah ;

Sun, Weijing ;

Fisher, George ;

Hezel, Aram ;

Chang, Shao-Chun ;

Vlahovic, Gordana ;

Takahashi, Osamu ;

Yang, Yin ;

Fitts, David ;

Philip, Philip Agop .

JAMA ONCOLOGY, 2019, 5 (10) :1431-1438

[7] Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases [J].

Pommier, Arnaud ;

Anaparthy, Naishitha ;

Memos, Nicoletta ;

Kelley, Z. Larkin ;

Gouronnec, Alizee ;

Yan, Ran ;

Auffray, Cedric ;

Albrengues, Jean ;

Egeblad, Mikala ;

Iacobuzio-Donahue, Christine A. ;

Lyons, Scott K. ;

Fearon, Douglas T. .

SCIENCE, 2018, 360 (6394) :1202-+

[8]

Ryschich E, 2005, CLIN CANCER RES, V11, P498

[9] The Role of Autophagy in Cancer [J].

Santana-Codina, Naiara ;

Mancias, Joseph D. ;

Kimmelman, Alec C. .

ANNUAL REVIEW OF CANCER BIOLOGY, VOL 1, 2017, 1 :19-39

[10] Whole genomes redefine the mutational landscape of pancreatic cancer [J].

Waddell, Nicola ;

Pajic, Marina ;

Patch, Ann-Marie ;

Chang, David K. ;

Kassahn, Karin S. ;

Bailey, Peter ;

Johns, Amber L. ;

Miller, David ;

Nones, Katia ;

Quek, Kelly ;

Quinn, Michael C. J. ;

Robertson, Alan J. ;

Fadlullah, Muhammad Z. H. ;

Bruxner, Tim J. C. ;

Christ, Angelika N. ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Manning, Suzanne ;

Nourse, Craig ;

Nourbakhsh, Ehsan ;

Wani, Shivangi ;

Wilson, Peter J. ;

Markham, Emma ;

Cloonan, Nicole ;

Anderson, Matthew J. ;

Fink, J. Lynn ;

Holmes, Oliver ;

Kazakoff, Stephen H. ;

Leonard, Conrad ;

Newell, Felicity ;

Poudel, Barsha ;

Song, Sarah ;

Taylor, Darrin ;

Waddell, Nick ;

Wood, Scott ;

Xu, Qinying ;

Wu, Jianmin ;

Pinese, Mark ;

Cowley, Mark J. ;

Lee, Hong C. ;

Jones, Marc D. ;

Nagrial, Adnan M. ;

Humphris, Jeremy ;

Chantrill, Lorraine A. ;

Chin, Venessa ;

Steinmann, Angela M. ;

Mawson, Amanda ;

Humphrey, Emily S. ;

Colvin, Emily K. ;

Chou, Angela .

NATURE, 2015, 518 (7540) :495-501

← 1 2 →