In situ photocrosslinkable hyaluronic acid-based surgical glue with tunable mechanical properties and high adhesive strength

被引：54

作者：

Chandrasekharan, Ajeesh ^{[1
]}

Seong, Keum-Yong ^{[1
]}

Yim, Sang-Gu ^{[1
]}

Kim, Sodam ^{[1
]}

Seo, Sungbaek ^{[1
]}

Yoon, Jinhwan ^{[2
]}

Yang, Seung Yun ^{[1
]}

机构：

[1] Pusan Natl Univ, Life & Ind Convergence Inst, Dept Biomat Sci, Miryang 50463, South Korea

[2] Pusan Natl Univ, Dept Chem Educ, Grad Dept Chem Mat, Busan 46241, South Korea

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2019年 / 57卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

adhesives; biomaterials; crosslinking; hyaluronic acid; photocrosslinkable polymer; surgical glue; tissue adhesive; WOUND CLOSURE; HYDROGEL; SEALANTS; SKIN; BIOADHESIVES; DEGRADATION; COMPONENTS; HEMOSTATS; CHEMISTRY; SINGLE;

D O I：

10.1002/pola.29290

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Hyaluronic acid (HA), a naturally occurring linear polysaccharide, has been widely used as a key biomaterial in a range of cosmetic and therapeutic applications. Its excellent biocompatibility and bio-functions related to tissue regeneration encourage the development of HA-based hydrogels to expand its applications. This study details an in situ forming surgical glue based on photocrosslinkable HA, providing tunable mechanical properties and firm tissue adhesion under wet and dynamic conditions. Depending on the degree of photocrosslinkable methacrylate groups in HA polymer chains, the mechanical properties of hyaluronate methacrylate (HAMA) hydrogels prepared by UV photocrosslinking was improved. Ex vivo adhesion tests revealed that HAMA hydrogels exhibited 3-fold higher shear adhesive strength compared to gelatin methacryloyl hydrogels and achieved firm adherence to the porcine skin tissue for several weeks. The high adhesive strength of HAMA hydrogels, under dry and wet conditions, suggests that it may have great promise as a tissue adhesive. (c) 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 522-530

引用

页码：522 / 530

页数：9

共 66 条

[1] Engineering a highly elastic human protein-based sealant for surgical applications [J].