Structural Insights into tRNA Dynamics on the Ribosome

被引：12

作者：

Agirrezabala, Xabier ^{[1
]}

Valle, Mikel ^{[1
]}

机构：

[1] CICbioGUNE Biscay Technol Pk, Struct Biol Unit, Derio 48610, Basque Country, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 05期

关键词：

ribosome; tRNA dynamics; protein synthesis; structure; conformational landscape; AMINOACYL-TRANSFER-RNA; ELONGATION-FACTOR TU; PHENYLALANINE TRANSFER-RNA; EUKARYOTIC TRANSLATION INITIATION; FACTORS EF-G; MESSENGER-RNA; GTP HYDROLYSIS; PROTEIN-SYNTHESIS; ESCHERICHIA-COLI; CRYO-EM;

D O I：

10.3390/ijms16059866

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High-resolution structures at different stages, as well as biochemical, single molecule and computational approaches have highlighted the elasticity of tRNA molecules when bound to the ribosome. It is well acknowledged that the inherent structural flexibility of the tRNA lies at the heart of the protein synthesis process. Here, we review the recent advances and describe considerations that the conformational changes of the tRNA molecules offer about the mechanisms grounded in translation.

引用

页码：9866 / 9895

页数：30

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