Exploiting C3-symmetry in the dynamic coordination of a chiral trisoxazoline to copper(II):: improved enantioselectivity, and catalyst stability in asymmetric Lewis acid catalysis

被引：86

作者：

Foltz, C

Stecker, B

Marconi, G

Bellemin-Laponnaz, S

Wadepohl, H

Gade, LH

机构：

[1] Heidelberg Univ, Anorgan Chem Inst, D-69120 Heidelberg, Germany

[2] Univ Louis Pasteur Strasbourg 1, Inst Le Bel, Lab Chim Organomet & Catalyse, F-67000 Strasbourg, France

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 40期

关键词：

D O I：

10.1039/b509571a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral C-3-symmetric trisoxazolines are highly efficient stereo-directing ligands in enantioselective Cu-II Lewis acid catalysis which is based on the concept of a stereoelectronic hemilability of the divalent copper; in direct comparison with the analogous bisoxazoline systems they are more efficient in the enantioselective alpha-amination as well as the enantioselective Mannich reaction of prochiral beta-ketoesters.

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页码：5115 / 5117

页数：3

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