Exploiting C3-symmetry in the dynamic coordination of a chiral trisoxazoline to copper(II):: improved enantioselectivity, and catalyst stability in asymmetric Lewis acid catalysis

被引:86
作者
Foltz, C
Stecker, B
Marconi, G
Bellemin-Laponnaz, S
Wadepohl, H
Gade, LH
机构
[1] Heidelberg Univ, Anorgan Chem Inst, D-69120 Heidelberg, Germany
[2] Univ Louis Pasteur Strasbourg 1, Inst Le Bel, Lab Chim Organomet & Catalyse, F-67000 Strasbourg, France
关键词
D O I
10.1039/b509571a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Chiral C-3-symmetric trisoxazolines are highly efficient stereo-directing ligands in enantioselective Cu-II Lewis acid catalysis which is based on the concept of a stereoelectronic hemilability of the divalent copper; in direct comparison with the analogous bisoxazoline systems they are more efficient in the enantioselective alpha-amination as well as the enantioselective Mannich reaction of prochiral beta-ketoesters.
引用
收藏
页码:5115 / 5117
页数:3
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