Schistosomiasis: from drug deployment to drug development

被引:55
作者
Caffrey, Conor R. [1 ]
Secor, W. Evan [2 ]
机构
[1] Univ Calif San Francisco, Calif Inst Quantitat Biosci, Sandler Ctr Drug Discovery, San Francisco, CA 94158 USA
[2] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA
关键词
anthelmintic; praziquantel; schistosomiasis; TRND; tropical disease; WHO-TDR; NEGLECTED TROPICAL DISEASES; HIGH-THROUGHPUT; IN-VITRO; RNA INTERFERENCE; MANSONI; PRAZIQUANTEL; EFFICACY; CHEMOTHERAPY; INFECTIONS; JAPONICUM;
D O I
10.1097/QCO.0b013e328349156f
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Purpose of review Schistosomiasis is a chronic and morbid disease that affects hundreds of millions of the poorest individuals in (sub) tropical regions, particularly sub-Saharan Africa. Just one drug, praziquantel (PZQ), is available. As discussed, efforts to expand mass drug administration programs may accelerate the emergence of resistance. In addition, PZQ's peculiar pharmacological profile and undefined mechanism of action(s) complicate discriminating incomplete efficacy from true resistance. Accordingly, and in spite of the challenges associated with developing new antischistosomals as discussed herein, alternatives to PZQ should be identified. Various strategies to do this are highlighted here. Recent findings The last 2 years have witnessed more engagement of the necessary infrastructure combined with the application of the latest strategies and technologies to facilitate antischistosomal drug discovery. Preclinical and clinical evaluation of new chemistries has benefited from various consortia and institutions that underwrite drug development for antiparasitics in general. Drug repositioning, target-based drug design, improved automation for compound screening, genomics and functional genomics are just some of the tools now being applied to identify possible new drugs and drug targets. Summary The new momentum toward the discovery of alternatives to PZQ is encouraging but needs to be sustained by a stronger advocacy for drug development, in addition to drug deployment.
引用
收藏
页码:410 / 417
页数:8
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