Hedgehog signaling: Costal-2 bridges the transiduction gap

被引：28
作者：
Kalderon, D [1 ]
机构：
[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA
来源：
CURRENT BIOLOGY | 2004年 / 14卷 / 02期
关键词：
D O I：
10.1016/j.cub.2003.12.047
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Drosophila genetics has provided the Hedgehog signaling pathway with roughly ordered components, but few mechanistic connections. Several studies now show that the kinesin-related protein Costal-2 provides a physical link between the transmembrane transducer Smoothened and the transcriptional effector Cubitus interruptus.
引用
收藏
页码：R67 / R69
页数：3
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  • [1] Frizzled receptor dimerization is sufficient to activate the Wnt/β-catenin pathway
    Carron, C
    Pascal, A
    Djiane, A
    Boucaut, JC
    Shi, DL
    Umbhauer, M
    [J]. JOURNAL OF CELL SCIENCE, 2003, 116 (12) : 2541 - 2550
  • [2] Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
    Dann, CE
    Hsieh, JC
    Rattner, A
    Sharma, D
    Nathans, J
    Leahy, DJ
    [J]. NATURE, 2001, 412 (6842) : 86 - 90
  • [3] Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    Denef, N
    Neubüser, D
    Perez, L
    Cohen, SM
    [J]. CELL, 2000, 102 (04) : 521 - 531
  • [4] Smoothened translates Hedgehog levels into distinct responses
    Hooper, JE
    [J]. DEVELOPMENT, 2003, 130 (17): : 3951 - 3963
  • [5] Sonic hedgehog induces the segregation of patched and smoothened in endosomes
    Incardona, JP
    Gruenberg, J
    Roelink, H
    [J]. CURRENT BIOLOGY, 2002, 12 (12) : 983 - 995
  • [6] Hedgehog signaling in animal development: paradigms and principles
    Ingham, PW
    McMahon, AP
    [J]. GENES & DEVELOPMENT, 2001, 15 (23) : 3059 - 3087
  • [7] Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
    Jia, JH
    Tong, C
    Jiang, J
    [J]. GENES & DEVELOPMENT, 2003, 17 (21) : 2709 - 2720
  • [8] Similarities between the Hedgehog and Wnt signaling pathways
    Kalderon, D
    [J]. TRENDS IN CELL BIOLOGY, 2002, 12 (11) : 523 - 531
  • [9] Hedgehog signal transduction via smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
    Lum, L
    Zhang, C
    Oh, S
    Mann, RK
    von Kessler, DP
    Taipale, J
    Weis-Garcia, F
    Gong, RY
    Wang, BL
    Beachy, PA
    [J]. MOLECULAR CELL, 2003, 12 (05) : 1261 - 1274
  • [10] Developmental roles and clinical significance of hedgehog signaling
    McMahon, AP
    Ingham, PW
    Tabin, CJ
    [J]. CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 53, 2003, 53 : 1 - 114
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