Glioblastoma multiforme (GBM) is one of the most lethal cancer due to poor diagnosis and rapid resistance developed towards the drug. Genes associated to cancer-related overexpression of proteins, enzymes, and receptors can be suppressed using an RNA silencing technique. This assists in obtaining tumour targetability, resulting in less harm caused to the surrounding healthy cells. RNA interference (RNAi) has scientific basis for providing potential therapeutic applications in improving GBM treatment. However, the therapeutic application of RNAi is challenging due to its poor permeability across blood-brain barrier (BBB). Nanobiotechnology has evolved the use of nanocarriers such as liposomes, polymeric nanoparticles, gold nanoparticles, dendrimers, quantum dots and other nanostructures in encasing the RNAi entities like siRNA and miRNA. The review highlights the role of these carriers in encasing siRNA and miRNA and promising therapy in delivering them to the glioma cells.
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Khan SA, 2020, MICRO NANO TECHNOL, P1, DOI 10.1016/B978-0-12-816960-5.00001-X
机构:
Department of Pathology, University of Western Ontario, London, Ont.
Department of Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MADepartment of Pathology, University of Western Ontario, London, Ont.
Khan Z.A.
;
Chan B.M.
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h-index: 0
机构:
Department of Microbiology and Immunology, University of Western Ontario, London, Ont.
Biotherapeutics Research Group, Robarts Research Institute, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
Chan B.M.
;
Uniyal S.
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h-index: 0
机构:
Department of Microbiology and Immunology, University of Western Ontario, London, Ont.
Biotherapeutics Research Group, Robarts Research Institute, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
Uniyal S.
;
Barbin Y.P.
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Department of Pathology, University of Western Ontario, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
Barbin Y.P.
;
Farhangkhoee H.
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Department of Pathology, University of Western Ontario, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
Farhangkhoee H.
;
Chen S.
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机构:
Department of Pathology, University of Western Ontario, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
Chen S.
;
Chakrabarti S.
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机构:
Department of Pathology, University of Western Ontario, London, Ont.
Department of Microbiology and Immunology, University of Western Ontario, London, Ont.
Department of Pathology, University of Western Ontario, Dental Sciences Building, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
机构:
Sookmyung Womens Univ, Coll Pharm, DIRI, RCCFC, Seoul 04310, South KoreaSookmyung Womens Univ, Coll Pharm, DIRI, RCCFC, Seoul 04310, South Korea
Kim, Jung Seok
;
Shin, Dae Hwan
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机构:
Mokpo Natl Univ, Coll Pharm, Jeonnam 58554, South Korea
Mokpo Natl Univ, Nat Med Res Inst, Jeonnam 58554, South KoreaSookmyung Womens Univ, Coll Pharm, DIRI, RCCFC, Seoul 04310, South Korea
Shin, Dae Hwan
;
Kim, Jin-Seok
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机构:
Sookmyung Womens Univ, Coll Pharm, DIRI, RCCFC, Seoul 04310, South KoreaSookmyung Womens Univ, Coll Pharm, DIRI, RCCFC, Seoul 04310, South Korea
机构:
Department of Pathology, University of Western Ontario, London, Ont.
Department of Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MADepartment of Pathology, University of Western Ontario, London, Ont.
Khan Z.A.
;
Chan B.M.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Microbiology and Immunology, University of Western Ontario, London, Ont.
Biotherapeutics Research Group, Robarts Research Institute, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
Chan B.M.
;
Uniyal S.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Microbiology and Immunology, University of Western Ontario, London, Ont.
Biotherapeutics Research Group, Robarts Research Institute, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
Uniyal S.
;
Barbin Y.P.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Pathology, University of Western Ontario, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
Barbin Y.P.
;
Farhangkhoee H.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Pathology, University of Western Ontario, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
Farhangkhoee H.
;
Chen S.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Pathology, University of Western Ontario, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
Chen S.
;
Chakrabarti S.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Pathology, University of Western Ontario, London, Ont.
Department of Microbiology and Immunology, University of Western Ontario, London, Ont.
Department of Pathology, University of Western Ontario, Dental Sciences Building, London, Ont.Department of Pathology, University of Western Ontario, London, Ont.
机构:
Sookmyung Womens Univ, Coll Pharm, DIRI, RCCFC, Seoul 04310, South KoreaSookmyung Womens Univ, Coll Pharm, DIRI, RCCFC, Seoul 04310, South Korea
Kim, Jung Seok
;
Shin, Dae Hwan
论文数: 0引用数: 0
h-index: 0
机构:
Mokpo Natl Univ, Coll Pharm, Jeonnam 58554, South Korea
Mokpo Natl Univ, Nat Med Res Inst, Jeonnam 58554, South KoreaSookmyung Womens Univ, Coll Pharm, DIRI, RCCFC, Seoul 04310, South Korea
Shin, Dae Hwan
;
Kim, Jin-Seok
论文数: 0引用数: 0
h-index: 0
机构:
Sookmyung Womens Univ, Coll Pharm, DIRI, RCCFC, Seoul 04310, South KoreaSookmyung Womens Univ, Coll Pharm, DIRI, RCCFC, Seoul 04310, South Korea