Chiral separation of reduced haloperidol by capillary zone electrophoresis with heptakis (2,6-di-O-methyl)-beta-cyclodextrin

被引：11

作者：

Wu, HL ^{[1
]}

Otsuka, K ^{[1
]}

Terabe, S ^{[1
]}

机构：

[1] HIMEJI INST TECHNOL,FAC SCI,DEPT MAT SCI,KAMIGORI,HYOGO 67812,JAPAN

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 1996年 / 19卷 / 10期

关键词：

D O I：

10.1080/10826079608005492

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple capillary zone electrophoresis was developed for the chiral separation of reduced haloperidol, a chiral metabolite of antipsychotic drug, haloperidol. Reduced haloperidol was separated in a phosphate buffer (pH 2.5) using heptakis (2,6-di-O-methyl)-beta-cyclodextrin as a chiral selector. Several parameters such as type of cyclodextrin, pH and concentration of buffer, applied voltage, concentration of chiral selector and detection wavelength that affected the chiral separation and detection of reduced haloperidol were discussed.

引用

页码：1567 / 1577

页数：11

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