ADAM and Eph: How ephrin-signaling cells become detached

被引：16
作者：
Mancia, F [1 ]
Shapiro, L
机构：
[1] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA
[2] Columbia Univ, Edward S Harkness Eye Inst, New York, NY 10032 USA
来源：
CELL | 2005年 / 123卷 / 02期
关键词：
D O I：
10.1016/j.cell.2005.10.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.
引用
收藏
页码：185 / 187
页数：3
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