Clinical fluctuations in MuSK myasthenia gravis are related to antigen-specific IgG4 instead fo IgG1

被引：109

作者：

Niks, E. H. ^{[1
]}

van Leeuwen, Y. ^{[2
]}

Leite, M. I. ^{[3
]}

Dekker, F. W. ^{[2
]}

Wintzen, A. R. ^{[1
]}

Wirtz, P. W. ^{[5
]}

Vincent, A. ^{[3
]}

van Tol, M. J. D. ^{[4
]}

Zijde, C. M. Jol-van der ^{[4
]}

Verschuuren, J. J. G. M. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Clin Epidemiol, NL-2300 RC Leiden, Netherlands

[3] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Dept Clin Neurol,Neurosci Grp, Oxford OX3 9DS, England

[4] Leiden Univ, Med Ctr, Dept Pediat, Sect Immunol Hematol Oncol Bone Marrow Transplant, NL-2300 RC Leiden, Netherlands

[5] Haga Hosp, Dept Neurol, NL-2504 LN The Hague, Netherlands

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 195卷 / 1-2期

关键词：

antibodies; IgG4; immunoglobulin isotypes; myasthenia gravis; MuSK; seronegative;

D O I：

10.1016/j.jneuroim.2008.01.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the longitudinal relation between disease severity and titers of antigen-specific IgG subclasses in sera of patients with myasthenia gravis and antibodies to Muscle Specific Kinase (MuSK MG). Six patients were included of whom 55 samples had been collected during 2.5-13.4 years. Anti-MuSK antibodies were determined by ELISA and with a cell-based immunofluorescence assay. Disease severity was scored on a semi Continuous scale. Only antigen-specific IgG4, and not IgG 1, titers were significantly associated with disease severity in a linear mixed effect model (p = 0.036). Levels of IgG4 antibodies were above IgG I in all samples except in one patient who went into clinical remission while switching from IgG4 to IgG1. The results support an important role for IgG4 in the pathogenesis of MuSK MG, in contrast to MG with anti-acetylcholine receptor antibodies. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：151 / 156

页数：6

共 17 条

[1] AALBERSE RC, 1983, J IMMUNOL, V130, P722
[2] Anti-MuSK antibodies: Correlation with myasthenia gravis severity
Bartoccioni, E.
Scuderi, F.
Minicuci, G. M.
Marino, M.
Ciaraffa, F.
Evoli, A.
[J]. NEUROLOGY, 2006, 67 (03) : 505 - 507
[3] CORRELATION OF PEPTIDE SPECIFICITY AND IGG SUBCLASS WITH PATHOGENIC AND NONPATHOGENIC AUTOANTIBODIES IN PEMPHIGUS-VULGARIS - A MODEL FOR AUTOIMMUNITY
BHOL, K
NATARAJAN, K
NAGARWALLA, N
MOHIMEN, A
AOKI, V
AHMED, AR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) : 5239 - 5243
[4] BROOKE MH, 1986, CLIN VIEW NEUROMUSCU
[5] The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo
DeChiara, TM
Bowen, DC
Valenzuela, DM
Simmons, MV
Poueymirou, WT
Thomas, S
Kinetz, E
Compton, DL
Rojas, E
Park, JS
Smith, C
DiStefano, PS
Glass, DJ
Burden, SJ
Yancopoulos, GD
[J]. CELL, 1996, 85 (04) : 501 - 512
[6] Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis
Evoli, A
Tonali, PA
Padua, L
Lo Monaco, M
Scuderi, F
Batocchi, AP
Marino, M
Bartoccioni, E
[J]. BRAIN, 2003, 126 : 2304 - 2311
[7] Predominant IgG4 subclass in autoantibodies of pemphigus vulgaris and foliaceus
Futei, Y
Amagai, M
Ishii, K
Kuroda-Kinoshita, K
Ohya, K
Nishikawa, T
[J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2001, 26 (01) : 55 - 61
[8] High serum IgG4 concentrations in patients with sclerosing pancreatitis.
Hamano, H
Kawa, S
Horiuchi, A
Unno, H
Furuya, N
Akamatsu, T
Fukushima, M
Nikaido, T
Nakayama, K
Usuda, N
Kiyosawa, K
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) : 732 - 738
[9] IgG4-subclass of glutamic acid decarboxylase antibody is more frequent in latent autolmmune diabetes in adults than in type 1 diabetes
Hillman, M
Törn, C
Thorgeirsson, H
Landin-Olsson, M
[J]. DIABETOLOGIA, 2004, 47 (11) : 1984 - 1989
[10] Myasthenia gravis - Recommendations for clinical research standards
Jaretzki, A
Barohn, RJ
Ernstoff, RM
Kaminski, HJ
Keesey, JC
Penn, AS
Sanders, DB
[J]. NEUROLOGY, 2000, 55 (01) : 16 - 23

← 1 2 →