X-ray Irradiation Improves Neurological Function Recovery of Injured Spinal Cord by Inhibiting Inflammation and Glial Scar Formation

被引：4

作者：

Wang, Yi ^{[1
]}

Niu, Yanping ^{[1
]}

Lin, Fanguo ^{[1
]}

Su, Peng ^{[1
]}

Chen, Liesong ^{[2
]}

Liu, Dong ^{[1
]}

Sun, Yongming ^{[1
]}

机构：

[1] Soochow Univ, Dept Orthoped, Affiliated Hosp 2, Suzhou, Peoples R China

[2] Soochow Univ, Dept Radiol, Affiliated Hosp 2, Suzhou, Peoples R China

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2022年 / 72卷 / 05期

关键词：

Spinal cord injury; X-ray; Inflammation; Glial scar; p38; MAPK; Akt; Nerve function; CENTRAL-NERVOUS-SYSTEM; AXONAL REGENERATION; ASTROCYTES; PATHWAY; ACTIVATION; VIMENTIN; GFAP; RESPONSES; KINASE; MAPK;

D O I：

10.1007/s12031-022-01975-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spinal cord injury (SCI) is a common clinical disease that can cause permanent disruption of nerve function. Inflammation and glial scar formation influence the recovery of injured spinal cord. X-ray irradiation can reduce inflammation, inhibit cell proliferation and increase cell apoptosis. However, the regulatory effects of X-ray irradiation on inflammation and glial scars and the underlying molecular mechanisms are still unclear. This study was aimed to investigate the therapeutic effect and molecular mechanism of X-ray irradiation on spinal cord injury. Behavioural experiments showed that X-ray irradiation can promote the recovery of nerve function after SCI. X-ray irradiation inhibited the inflammatory response by reducing the expression of inflammatory factors (TNF-alpha and IL-1 beta) at the lesion site, thereby reducing neuronal apoptosis. X-ray irradiation inhibited the formation of the glial scar (GFAP and vimentin) in the lesion. P38MAPK and Akt signalling pathways were involved in these processes. Furthermore, the 10 Gy dose had the most significant effects among the 2 Gy, 10 Gy and 20 Gy doses. In summary, X-ray irradiation may exert an active therapeutic effect on SCI by inhibiting inflammation and glial scar formation, which may be related to the inhibition of p38MAPK and Akt signalling pathways.

引用

页码：1008 / 1017

页数：10

共 41 条

[41] SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway [J].

Ziyu Li ;

Shuisheng Yu ;

Yanchang Liu ;

Xuyang Hu ;

Yiteng Li ;

Zhaoming Xiao ;

Yihao Chen ;

Dasheng Tian ;

Xinzhong Xu ;

Li Cheng ;

Meige Zheng ;

Juehua Jing .

Journal of Neuroinflammation, 19

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