The first proline-catalyzed Friedlander annulation: Regioselective synthesis of 2-substituted quinoline derivatives

被引：40

作者：

Jiang, Biao ^{[1
]}

Dong, Jia-jia ^{[1
]}

Jin, Yun ^{[1
]}

Du, Xiao-long ^{[1
]}

Xu, Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 2008卷 / 16期

关键词：

aldol reactions; quinoline; cyclization; proline;

D O I：

10.1002/ejoc.200800121

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first proline-catalyzed Friedlander annulation for the synthesis of 2-substituted 4-trifluoromethyl quinoline derivatives is described. Excellent re gio selectivity as well as good yields were shown in a variety of cases, and a tandem aldol-cyclization pathway might be involved. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).

引用

页码：2693 / 2696

页数：4

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