Continuous in situ generation and reaction of phosgene in a microflow system

被引：57
|
作者：
Fuse, Shinichiro [1 ]
Tanabe, Nobutake [1 ]
Takahashi, Takashi [1 ]
机构：
[1] Tokyo Inst Technol, Dept Appl Chem, Meguro Ku, Tokyo 1528552, Japan
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 47期
关键词：
SOLID-PHASE; CYCLOSPORINE-O; OMPHALOTIN-A; AMINO-ACIDS; MICROREACTOR; DIAZOMETHANE; TRIPHOSGENE; COUPLINGS; EFFICIENT; CHEMISTRY;
D O I：
10.1039/c1cc15662d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Continuous in situ generation of phosgene and its use in acid chloride formation in a microflow system were demonstrated. The acid chloride was subsequently coupled with an amine in high yield without severe epimerization.
引用
收藏
页码：12661 / 12663
页数：3
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