Antileishmanial Activity of Tamoxifen by Targeting Sphingolipid Metabolism: A Review

被引：5

作者：

Zewdie, Kaleab Alemayehu ^{[1
]}

Hailu, Haftom Gebregergs ^{[1
]}

Ayza, Muluken Altaye ^{[1
]}

Tesfaye, Bekalu Amare ^{[1
]}

机构：

[1] Mekelle Univ, Sch Pharm, Dept Pharmacol & Toxicol, POB 1871, Mekelle, Ethiopia

来源：

CLINICAL PHARMACOLOGY-ADVANCES AND APPLICATIONS | 2022年 / 14卷

关键词：

tamoxifen; leishmaniasis; sphingolipid metabolism; estrogen receptor modulator; CUTANEOUS LEISHMANIASIS; AMPHOTERICIN-B; THERAPY; EFFICACY;

D O I：

10.2147/CPAA.S344268

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Leishmaniasis is a widespread group of neglected parasitic diseases caused by protozoa of the genus Leishmania. Around 2 million new cases are reported each year and around 12 million people are at risk of being infected. Although various therapies have been used to treat leishmaniasis, they have been associated with increased cytotoxicity and drug resistance problems. Hence, the present review was intended to show the potential of tamoxifen as an alternative option for the treatment of leishmaniasis. Tamoxifen is a known selective estrogen receptor modulator and has been widely used for the treatment of early-stage breast cancer. Various experimental and clinical studies revealed that it has an antileishmanial effect by decreasing parasitic burden, with low cost and few side effects. The antileishmanial action of tamoxifen has been related to its potential effect on sphingolipid metabolism. Besides, it affects mitochondrial function by inducing alterations in the plasma membrane potential. However, further detailed studies are required to show the ultimate effects on health outcomes.

引用

页码：11 / 17

页数：7

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