Human hepatocyte nuclear factor-4 (hHNF4) gene maps to 20q12-q13.1 between PLCGI and D20S17

被引：9
作者：
Argyrokastritis, A
Kamakari, S
Kapsetaki, M
Kritis, A
Talianidis, I
Moschonas, NK
机构：
[1] FDN RES & TECHNOL HELLAS,INST MOL BIOL & BIOTECHNOL,GR-71110 IRAKLION,GREECE
[2] UNIV CRETE,DEPT BIOL,GR-71110 IRAKLION,GREECE
来源：
HUMAN GENETICS | 1997年 / 99卷 / 02期
关键词：
D O I：
10.1007/s004390050345
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Human hepatocyte nuclear factor 4 (hHNF-4) is a member of the nuclear hormone receptor superfamily and an important transcription factor and developmental regulator of liver-specific genes. Distinct hHNF-4 cDNAs corresponding to various HNF-4 isoforms have been recently characterised. Three cDNAs, hHNF-4A, B and C, are considered splice variants of a single hHNF-4 gene. We have mapped hHNF-4 to 20q12-q13.1 between PLCG1 and D20S17 by genetic linkage analysis, taking advantage of an adjacent PstI restriction fragment length polymorphism, (RFLP), and by fluorescence in situ hybridisation. hHFN-4 maps to chromosome 20 in a region syntenic with mouse chromosome 2 where the hnf-4 homologue has been assigned.
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收藏
页码：233 / 236
页数：4
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