Sequence-specific oligodeoxyribonucleotide cleavage by a major-groove-positioned metal-binding ligand tethered to C-5 of deoxyuridine

被引：5

作者：

Bergstrom, DE

Chen, JY

机构：

[1] PURDUE UNIV,DEPT CHEM,W LAFAYETTE,IN 47907

[2] WALTHER CANC INST,INDIANAPOLIS,IN 46208

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 18期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0960-894X(96)00402-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Highly efficient cleavage of the single-stranded oligonucleotide 5'-d(CTGGCTCACAAATACCACTGAGATCTTTTTC)-3' (O1) at nucleotides G20, A21, and G22 was achieved by an iron-bipyridine complex linked to a targeting oligonucleotide 5'-d(AAA AAG ATC T*CA)-3' (O2) through -SCH2CH2NHC(O)- at C5 of a 2'-deoxyuridine (T*). Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2211 / 2214

页数：4

共 22 条

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