Sequence-specific oligodeoxyribonucleotide cleavage by a major-groove-positioned metal-binding ligand tethered to C-5 of deoxyuridine

被引：5
作者：
Bergstrom, DE
Chen, JY
机构：
[1] PURDUE UNIV,DEPT CHEM,W LAFAYETTE,IN 47907
[2] WALTHER CANC INST,INDIANAPOLIS,IN 46208
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 18期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0960-894X(96)00402-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Highly efficient cleavage of the single-stranded oligonucleotide 5'-d(CTGGCTCACAAATACCACTGAGATCTTTTTC)-3' (O1) at nucleotides G20, A21, and G22 was achieved by an iron-bipyridine complex linked to a targeting oligonucleotide 5'-d(AAA AAG ATC T*CA)-3' (O2) through -SCH2CH2NHC(O)- at C5 of a 2'-deoxyuridine (T*). Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：2211 / 2214
页数：4
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