Pyridazines.: Part 36:: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones

被引：52
作者：
Coelho, A
Sotelo, E
Fraiz, N
Yáñez, M
Laguna, R
Cano, E
Raviña, E
机构：
[1] Univ Santiago de Compostela, Drug Res & Dev Grp, Lab Quim, Dept Quim Organ, Santiago De Compostela 15782, Spain
[2] Univ Santiago de Compostela, Fac Farm, Dept Farmacol, Santiago De Compostela 15782, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 02期
关键词：
pyridazinones; antiplatelet agents;
D O I：
10.1016/j.bmcl.2003.11.009
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A convenient and efficient palladium-catalysed retro-ene-assisted method has been developed to prepare a series of 5-substituted-6-phenyl-3(2H)-pyridazinones as potential antiplatelet drugs. The most active compounds were those that contain a 3-phenyl-3-oxo-propenyl fragment or a phenylthio group at position 5 of the heterocyclic ring. (C) 2003 Elsevier Ltd. All rights reserved.
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收藏
页码：321 / 324
页数：4
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