The Second Annual Symposium of the Midwest Aging Consortium: The Future of Aging Research in the Midwestern United States

被引:1
作者
Green, Cara L. [1 ,2 ]
Englund, Davis A. [3 ]
Das, Srijit [4 ]
Herrerias, Mariana M. [5 ]
Yousefzadeh, Matthew J. [6 ,7 ]
Grant, Rogan A. [5 ]
Clark, Josef [1 ,2 ]
Pak, Heidi H. [1 ,2 ]
Liu, Peiduo [8 ]
Bai, Hua [8 ]
Prahlad, Veena [4 ]
Lamming, Dudley W. [1 ,2 ]
Chusyd, Daniella E. [9 ]
机构
[1] Univ Wisconsin, Dept Med, Madison, WI USA
[2] William S Middleton Mem Vet Adm Med Ctr, Madison, WI USA
[3] Mayo Clin, Robert & Arlene Kogod Ctr Aging, Rochester, MN USA
[4] Univ Iowa, Dept Biol, Aging Mind & Brain Initiat, Iowa City, IA 52242 USA
[5] Northwestern Univ, Dept Med, Div Pulm & Crit Care Med, Feinberg Sch Med, Chicago, IL 60611 USA
[6] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN USA
[7] Univ Minnesota, Inst Biol Aging & Metab, Minneapolis, MN USA
[8] Iowa State Univ, Dept Genet Dev & Cell Biol, Ames, IA USA
[9] Indiana Univ, Dept Epidemiol & Biostat, Bloomington, IN 47405 USA
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2021年 / 76卷 / 12期
基金
美国国家卫生研究院;
关键词
Aging; Animal models; Gerontology; Metabolism; Senescence; CHAIN AMINO-ACIDS; TERM COGNITIVE IMPAIRMENT; LIFE-SPAN; CALORIC RESTRICTION; FUNCTIONAL DISABILITY; DECREASED CONSUMPTION; DNA-DAMAGE; AGED MICE; HEALTH; MORTALITY;
D O I
10.1093/gerona/glab210
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
While the average human life span continues to increase, there is little evidence that this is leading to a contemporaneous increase in "healthy years" experienced by our aging population. Consequently, many scientists focus their research on understanding the process of aging and trialing interventions that can promote healthspan. The 2021 Midwest Aging Consortium consensus statement is to develop and further the understanding of aging and age-related disease using the wealth of expertise across universities in the Midwestern United States. This report summarizes the cutting-edge research covered in a virtual symposium held by a consortium of researchers in the Midwestern United States, spanning topics such as senescence biomarkers, serotonin-induced DNA protection, immune system development, multisystem impacts of aging, neural decline following severe infection, the unique transcriptional impact of calorie restriction of different fat depots, the pivotal role of fasting in calorie restriction, the impact of peroxisome dysfunction, and the influence of early life trauma on health. The symposium speakers presented data from studies conducted in a variety of common laboratory animals as well as less-common species, including Caenorhabditis elegans, Drosophila, mice, rhesus macaques, elephants, and humans. The consensus of the symposium speakers is that this consortium highlights the strength of aging research in the Midwestern United States as well as the benefits of a collaborative and diverse approach to geroscience.
引用
收藏
页码:2156 / 2161
页数:6
相关论文
共 67 条
  • [11] Serotonin signaling by maternal neurons upon stress ensures progeny survival
    Das, Srijit
    Ooi, Felicia K.
    Corchado, Johnny Cruz
    Fuller, Leah C.
    Weiner, Joshua A.
    Prahlad, Veena
    [J]. ELIFE, 2020, 9
  • [12] Functional Disability, Cognitive Impairment, and Depression After Hospitalization for Pneumonia
    Davydow, Dimitry S.
    Hough, Catherine L.
    Levine, Deborah A.
    Langa, Kenneth M.
    Iwashyna, Theodore J.
    [J]. AMERICAN JOURNAL OF MEDICINE, 2013, 126 (07) : 615 - +
  • [13] A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
    Deelen, Joris
    Kettunen, Johannes
    Fischer, Krista
    van der Spek, Ashley
    Trompet, Stella
    Kastenmueller, Gabi
    Boyd, Andy
    Zierer, Jonas
    van den Akker, Erik B.
    Ala-Korpela, Mika
    Amin, Najaf
    Demirkan, Ayse
    Ghanbari, Mohsen
    van Heemst, Diana
    Ikram, M. Arfan
    van Klinken, Jan Bert
    Mooijaart, Simon P.
    Peters, Annette
    Salomaa, Veikko
    Sattar, Naveed
    Spector, Tim D.
    Tiemeier, Henning
    Verhoeven, Aswin
    Waldenberger, Melanie
    Wurtz, Peter
    Smith, George Davey
    Metspalu, Andres
    Perola, Markus
    Menni, Cristina
    Geleijnse, Johanna M.
    Drenos, Fotios
    Beekman, Marian
    Jukema, J. Wouter
    van Duijn, Cornelia M.
    Slagboom, P. Eline
    [J]. NATURE COMMUNICATIONS, 2019, 10 (1)
  • [14] T cells with dysfunctional mitochondria induce multimorbidity and premature senescence
    Desdin-Mico, Gabriela
    Soto-Heredero, Gonzalo
    Francisco Aranda, Juan
    Oller, Jorge
    Carrasco, Elisa
    Gabande-Rodriguez, Enrique
    Maria Blanco, Eva
    Alfranca, Arantzazu
    Cusso, Lorena
    Desco, Manuel
    Ibanez, Borja
    Gortazar, Arancha R.
    Fernandez-Marcos, Pablo
    Navarro, Maria N.
    Hernaez, Bruno
    Alcami, Antonio
    Baixauli, Francesc
    Mittelbrunn, Maria
    [J]. SCIENCE, 2020, 368 (6497) : 1371 - +
  • [15] Cellular senescence in ageing: from mechanisms to therapeutic opportunities
    Di Micco, Raffaella
    Krizhanovsky, Valery
    Baker, Darren
    di Fagagna, Fabrizio d'Adda
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2021, 22 (02) : 75 - 95
  • [16] Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health
    Fontana, Luigi
    Cummings, Nicole E.
    Apelo, Sebastian I. Arriola
    Neuman, Joshua C.
    Kasza, Ildiko
    Schmidt, Brian A.
    Cava, Edda
    Spelta, Francesco
    Tosti, Valeria
    Syed, Faizan A.
    Baar, Emma L.
    Veronese, Nicola
    Cottrell, Sara E.
    Fenske, Rachel J.
    Bertozzi, Beatrice
    Brar, Harpreet K.
    Pietka, Terri
    Bullock, Arnold D.
    Figenshau, Robert S.
    Andriole, Gerald L.
    Merrins, Matthew J.
    Alexander, Caroline M.
    Kimple, Michelle E.
    Lamming, Dudley W.
    [J]. CELL REPORTS, 2016, 16 (02): : 520 - 530
  • [17] Extending Healthy Life Span-From Yeast to Humans
    Fontana, Luigi
    Partridge, Linda
    Longo, Valter D.
    [J]. SCIENCE, 2010, 328 (5976) : 321 - 326
  • [18] Genotype and age influence the effect of caloric intake on mortality in mice
    Forster, MJ
    Morris, P
    Sohal, RS
    [J]. FASEB JOURNAL, 2003, 17 (02) : 690 - +
  • [19] Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function
    Fu, Zheng
    Ye, Jian
    Dean, Joseph W.
    Bostick, John W.
    Weinberg, Samuel E.
    Xiong, Lifeng
    Oliff, Kristen N.
    Chen, Zongming E.
    Avram, Dorina
    Chandel, Navdeep S.
    Zhou, Liang
    [J]. CELL REPORTS, 2019, 28 (01): : 159 - +
  • [20] Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
    Girard, Timothy D.
    Jackson, James C.
    Pandharipande, Pratik P.
    Pun, Brenda T.
    Thompson, Jennifer L.
    Shintani, Ayumi K.
    Gordon, Sharon M.
    Canonico, Angelo E.
    Dittus, Robert S.
    Bernard, Gordon R.
    Ely, E. Wesley
    [J]. CRITICAL CARE MEDICINE, 2010, 38 (07) : 1513 - 1520