Targeting the blood-spinal cord barrier: A therapeutic approach to spinal cord protection against ischemia-reperfusion injury

被引：30
作者：
Hu, Ji [1 ]
Yu, Qijing [2 ]
Xie, Lijie [1 ]
Zhu, Hongfei [3 ]
机构：
[1] Huazhong Univ Sci & Technol, Liyuan Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430077, Hubei Province, Peoples R China
[2] Wuhan Univ, Renmin Hosp, Dept Anesthesiol, Wuhan 430060, Hubei Province, Peoples R China
[3] Wuhan Univ, Sch & Hosp Stomatol, Dept Anesthesiol, Wuhan 430060, Hubei Province, Peoples R China
来源：
LIFE SCIENCES | 2016年 / 158卷
关键词：
Blood-spinal cord barrier; Spinal cord ischemia; Reperfusion injury; STEM-CELL TRANSPLANTATION; MARROW STROMAL CELLS; BRAIN-BARRIER; ISCHEMIA/REPERFUSION INJURY; SYSTEMIC HYPOTHERMIA; CEREBRAL-ISCHEMIA; MILD HYPOTHERMIA; NEUROLOGICAL FUNCTION; INFLAMMATORY DAMAGE; EXPERIMENTAL STROKE;
D O I：
10.1016/j.lfs.2016.06.018
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
One of the principal functions of physical barriers between the blood and central nervous system protects system (i.e., blood brain barrier and blood-spinal cord barrier) is the protection from toxic and pathogenic agents in the blood. Disruption of blood-spinal cord barrier (BSCB) plays a key role in spinal cord ischemia-reperfusion injury (SCIRI). Following SARI, the permeability of the BSCB increases. Maintaining the integrity of the BSCB alleviates the spinal cord injury after spinal cord ischemia. This review summarizes current knowledge of the structure and function of the BSCB and its changes following SCIRI, as well as the prevention and cure of SCIRI and the role of the BSCB. (C) 2016 Elsevier Inc. All rights reserved.
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页码：1 / 6
页数：6
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