FDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis

被引：5

作者：

Kameda, Tomohiro ^{[1
]}

Nakashima, Shusaku ^{[1
]}

Mitamura, Katsuya ^{[2
]}

Yamamoto, Yuka ^{[2
]}

Norikane, Takashi ^{[2
]}

Shimada, Hiromi ^{[1
]}

Wakiya, Risa ^{[1
]}

Kato, Mikiya ^{[1
]}

Miyagi, Taichi ^{[1
]}

Sugihara, Koichi ^{[1
]}

Mino, Rina ^{[1
]}

Mizusaki, Mao ^{[1
]}

Kadowaki, Norimitsu ^{[1
]}

Dobashi, Hiroaki ^{[1
]}

机构：

[1] Kagawa Univ, Fac Med, Dept Internal Med, Div Hematol Rheumatol & Resp Med, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan

[2] Kagawa Univ, Fac Med, Dept Radiol, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

TOTAL LESION GLYCOLYSIS; PET/COMPUTED TOMOGRAPHY; LYMPHOCYTE COUNT; TUMOR VOLUME; LUNG-CANCER; THERAPY;

D O I：

10.1038/s41598-022-19727-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this study, we investigated the usefulness of FDG-PET/CT for predicting spontaneous regression in methotrexate-associated lymphoproliferative disorder (MTX-LPD). Twenty patients with rheumatoid arthritis who were diagnosed with MTX-LPD were enrolled in the study. These patients were divided into those who showed spontaneous regression (SR group: ten patients) and those who received chemotherapy after discontinuation of MTX (CTx group: ten patients). Between-group differences in potential biomarkers were compared, including clinical markers at the onset of LPD [serum LDH and interleukin 2 receptor (sIL-2R)], change in absolute number of peripheral lymphocytes (Delta ALC) over follow-up, and the FDG-PET/CT-derived parameters of maximum standardized uptake value (SUVmax), mean SUV (SUVmean), peak SUV (SUVpeak), sum of the metabolic tumor volume (MTVsum), and sum of total lesion glycolysis (TLGsum). The levels of sIL-2R, MTVsum, and TLGsum were significantly lower in the SR group than in the CTx group. In addition, Delta ALC was higher in the SR group. In conclusion, MTV and TLG values measured by FDG-PET/CT may be suitable for use as predictors of SR in patients with MTX-LPD.

引用

页数：7

共 22 条

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