Synthesis of P-chiral, phosphorothioic acid analogs of N-phospholeucinamide

被引：8

作者：

Thompson, CM ^{[1
]}

Lin, J ^{[1
]}

机构：

[1] LOYOLA UNIV,DEPT CHEM,CHICAGO,IL 60626

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 50期

关键词：

N-phospholeucinamide; phosphoramidothioic acid; stereoisomer;

D O I：

10.1016/S0040-4039(96)02107-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diastereomeric mixture of R(p)- and S-p- N-[O-methyl phosphorothioic acid]leucinamides were synthesized by thiophosphorlation of leucinamide followed by monodealkylation of the phosphate methyl ester. Individual diastereomers were prepared by a sequence utilizing selective protection of the thioic acid moiety as the S-benzyl group, chromatographic separation, and deprotection. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8979 / 8982

页数：4

共 15 条

[1] A NEW METHOD FOR THE PROTECTION OF THE SULFHYDRYL GROUP DURING PEPTIDE SYNTHESIS [J].