Furanocoumarins from Dorstenia foetida

被引：22

作者：

Heinke, Ramona ^{[1
]}

Franke, Katrin ^{[1
]}

Porzel, Andrea ^{[1
]}

Wessjohann, Ludger A. ^{[1
]}

Ali, Nasser A. Awadh ^{[2
]}

Schmidt, Juergen ^{[1
]}

机构：

[1] Leibniz Inst Plant Biochem, Dept Bioorgan Chem, D-06120 Halle, Germany

[2] Sanaa Univ, Fac Pharm, Dept Pharmacognosy, Sanaa, Yemen

来源：

PHYTOCHEMISTRY | 2011年 / 72卷 / 09期

关键词：

Dorstenia foetida; Moraceae; Phytochemistry; Furanocoumarins; 7-Hydroxy-5-methoxy-6-carboxymethyl-3-[3-(beta-D-glucopyranosyloxy)-2-hydroxy-3-methyl-butyl]-coumarin; LINEAR FURANOCOUMARINS; ANGELICA-DAHURICA; COUMARINS; INHIBITION; CONSTITUENTS; MEDICINES; PLANTS; GIGAS;

D O I：

10.1016/j.phytochem.2011.03.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The linear furanocoumarins 5-(2,3-epoxy-3-methyl-butoxy)-chalepensin, 5-methoxy-3-(3-methyl-2,3-dihydroxybutyl)-psoralen-diacetate (7), 5-methoxy-3-[3-(beta-D-glucopyranosyloxy)-2-acetyloxy-3-methyl-butyl]-psoralen and 5-(3-methyl-2,3-dihydroxybutyloxy)-3-[3-(beta-D-glucopyranosyloxy)-2-hydroxy-3-methyl-butyl]-psoralen, and the coumarin derivative 7-hydroxy-5-methoxy-6-carboxy-methyl-3-[3-(beta-D-glucopyranosyloxy)-2-hydroxy-3-methyl-butyl]-coumarin were isolated from the leaves of Dorstenia foetida (Moraceae) along with the known compounds psoralen, bergapten, isopimpinellin, phellopterin, 5-methoxychalepensin and turbinatocoumarin. Further furanocoumarins were characterized by ESI-MS/MS investigations. The nonpolar extracts of D. foetida exhibit antifungal, antibacterial and cytotoxic activity, however, no anthelminthic activity. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：929 / 934

页数：6

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