Citrinal B, natural 11 beta-hydroxysteroid dehydrogennase type 1 inhibitor identified from structure-based virtual screening

被引：4

作者：

Cao, Jie ^{[1
]}

Gao, Limin ^{[1
]}

Chen, Yizhan ^{[2
]}

Sun, Weiguang ^{[3
]}

Wang, Fuqian ^{[4
]}

Li, Hua ^{[3
]}

Zhang, Yonghui ^{[3
]}

机构：

[1] Huazhong Univ Sci & Technol, Tonsil Med Coll, Union Hosp, Wuhan 430030, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tonsil Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China

[3] Huazhong Univ Sci & Technol, Tonsil Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China

[4] Wuhan First Hosp, Dept Pharm, Wuhan 430022, Hubei, Peoples R China

来源：

FITOTERAPIA | 2017年 / 123卷

基金：

中国国家自然科学基金;

关键词：

11; beta-HSD1; inhibitor; Citrinal B; Natural product; Virtual screening; ADIPOSE-TISSUE; 11-BETA-HSD1; EXPRESSION; METABOLISM; OBESITY;

D O I：

10.1016/j.fitote.2017.09.018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Citrinal B, a tricyclic compound from endophytic fungus Colletotrichum capsici in our previous studies, exhibited significant inhibitory activity against 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) in vitro and showed strong binding affinity to 11 beta-HSD1. Moreover, citrinal B treatments decreased the lipid droplet accumulation associate with the inhibition of 11 beta-HSD1 expression in differentiate induced 3T3-L1 preadipocytes. Furthermore, the molecular docking demonstrated that citrinal B coordinated in the active site of 11 beta-HSD1 is essential for the ability of diminishing the enzyme activity.

引用

页码：29 / 34

页数：6

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