Aims Cholesteryl ester transfer protein (CETP) has a well-established rote in lipoprotein metabolism, but the effect of its overexpression or inhibition on the efficiency of reverse cholesterol transport (RCT) is unclear. Methods and results Neither overexpression of CETP nor treatment with CETP inhibitor Torcetrapib of RAW 264.7 macrophages or HepG2 hepatocytes affected cholesterol efflux in vitro. Overexpression of CETP or treatment with Torcetrapib, respectively, stimulated or inhibited HDL cholesteryl ester uptake by HepG2 but not by RAW 264.7 cells. When RAW 264.7 cells transfected with CETP or ATP binding cassette transporter A1 (ABCA1) were injected intraperitoneally into mice, cholesterol egress from macrophages was elevated for ABCA1- but not for CETP-transfected macrophages. Systemic expression of CETP in mice by adenoviral infection stimulated egress of cholesterol to plasma and liver without affecting HDL levels. Treatment with Torcetrapib did not affect appearance of macrophage cholesterol in plasma and liver, but inhibited its excretion into feces. Treatment of hamsters with Torcetrapib led to elevation of HDL cholesterol, an increase in the capacity of plasma to support cholesterol efflux, and increased egress of cholesterol from macrophages to plasma and feces in vivo. Conclusion Both increased (mice study) and decreased (hamster study) CETP activity could result in enhanced RCT.
机构:
Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Nankai Univ, Coll Life Sci, 94 Weijin Rd, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Liu, Mengyang
Chen, Yuanli
论文数: 0引用数: 0
h-index: 0
机构:
Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Nankai Univ, Coll Med, Tianjin 300071, Peoples R China
Nankai Univ, Collaborat Innovat Ctr Biotherapy, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Chen, Yuanli
Zhang, Ling
论文数: 0引用数: 0
h-index: 0
机构:
Nankai Univ, Coll Life Sci, 94 Weijin Rd, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Zhang, Ling
Wang, Qixue
论文数: 0引用数: 0
h-index: 0
机构:
Nankai Univ, Coll Life Sci, 94 Weijin Rd, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Wang, Qixue
Ma, Xingzhe
论文数: 0引用数: 0
h-index: 0
机构:
Nankai Univ, Coll Life Sci, 94 Weijin Rd, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Ma, Xingzhe
Li, Xiaoju
论文数: 0引用数: 0
h-index: 0
机构:
Nankai Univ, Coll Life Sci, 94 Weijin Rd, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Li, Xiaoju
Xiang, Rong
论文数: 0引用数: 0
h-index: 0
机构:
Nankai Univ, Coll Med, Tianjin 300071, Peoples R China
Nankai Univ, Collaborat Innovat Ctr Biotherapy, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Xiang, Rong
Zhu, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Zhu, Yan
Qin, Shucun
论文数: 0引用数: 0
h-index: 0
机构:
Taishan Med Univ, Tai An 271000, Shandong, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Qin, Shucun
Yu, Yang
论文数: 0引用数: 0
h-index: 0
机构:
Taishan Med Univ, Tai An 271000, Shandong, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Yu, Yang
Jiang, Xian-cheng
论文数: 0引用数: 0
h-index: 0
机构:
Suny Downstate Med Ctr, Brooklyn, NY 11203 USANankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Jiang, Xian-cheng
Duan, Yajun
论文数: 0引用数: 0
h-index: 0
机构:
Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Nankai Univ, Coll Life Sci, 94 Weijin Rd, Tianjin 300071, Peoples R China
Nankai Univ, Collaborat Innovat Ctr Biotherapy, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Duan, Yajun
Han, Jihong
论文数: 0引用数: 0
h-index: 0
机构:
Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
Nankai Univ, Coll Life Sci, 94 Weijin Rd, Tianjin 300071, Peoples R China
Nankai Univ, Collaborat Innovat Ctr Biotherapy, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
机构:
Virginia Commonwealth Univ, Dept Internal Med, Med Ctr, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Med Ctr, Richmond, VA 23298 USA
Zhao, Bin
Song, Jingmei
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Med Ctr, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Med Ctr, Richmond, VA 23298 USA
Song, Jingmei
Ghosh, Shobha
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Dept Internal Med, Med Ctr, Richmond, VA 23298 USAVirginia Commonwealth Univ, Dept Internal Med, Med Ctr, Richmond, VA 23298 USA