Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature

被引：20

作者：

Gurion, Reut ^{[1
]}

Tangpricha, Vin ^{[2
,3
]}

Yow, Eric ^{[4
]}

Schanberg, Laura E. ^{[5
]}

McComsey, Grace A. ^{[1
,6
]}

Robinson, Angela Byun ^{[1
]}

机构：

[1] Rainbow Babies & Childrens Hosp Case Med Ctr, Dept Pediat, Div Pediat Infect Dis Rheumatol & Global Hlth, Cleveland, OH 44106 USA

[2] Emory Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA

[3] Atlanta VA Med Ctr, Decatur, GA USA

[4] Duke Clin Res Inst, Durham, NC USA

[5] Duke Univ, Med Ctr, Div Pediat Rheumatol, Durham, NC 27710 USA

[6] Univ Hosp Case Med Ctr, Div Med, Cleveland, OH 44106 USA

来源：

PEDIATRIC RHEUMATOLOGY | 2015年 / 13卷

关键词：

Avascular necrosis; Systemic lupus erythematosus; Pediatrics; CAPITAL FEMORAL EPIPHYSIS; CALVE-PERTHES DISEASE; VITAMIN-D DEFICIENCY; SICKLE-CELL-DISEASE; RISK-FACTORS; MARROW-TRANSPLANTATION; NONTRAUMATIC NECROSIS; FAT-EMBOLISM; OSTEONECROSIS; BONE;

D O I：

10.1186/s12969-015-0008-x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Avascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to be unraveled. AVN in the pediatric lupus population is understudied. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, provides an excellent venue to conduct an exploratory analysis to assess associations between AVN and demographics, SLE disease activity and vitamin D deficiency. Herein we present a brief report describing our findings, as well as reviewing the literature on AVN in SLE and other entities.

引用

页数：10

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