Discovery of a tetrazole-based growth hormone secretagogue: 4-(Hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2-benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180)

被引：27

作者：

Li, Jun

Chen, Stephanie Y.

Li, James J.

Wang, Haixia

Hernandez, Andres S.

Tao, Shiwei

Musial, Christa M.

Qu, Fucheng

Swartz, Stephen

Chao, Sam T.

Flynn, Neil

Murphy, Brian J.

Slusarchyk, Dorothy A.

Seethala, Ramakrishna

Yan, Mujing

Sleph, Paul

Grover, Gary

Smith, Mark A.

Beehler, Blake

Giupponi, Leah

Dickinson, Kenneth E.

Zhang, Hongjian

Humphreys, William G.

Patel, Bharat P.

Schwinden, Mark

Stouch, Terry

Cheng, Peter T. W.

Biller, Scott A.

Ewing, William R.

Gordon, David

Robl, Jeffrey A.

Tino, Joseph A.

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Discovery Chem, Princeton, NJ 08543 USA

[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Metab Dis, Princeton, NJ 08543 USA

[3] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Metab & Pharmacokinet, Princeton, NJ 08543 USA

[4] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Proc Chem, Princeton, NJ 08543 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 50卷 / 24期

关键词：

D O I：

10.1021/jm7010595

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development.

引用

页码：5890 / 5893

页数：4

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