Discovery of a tetrazole-based growth hormone secretagogue: 4-(Hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2-benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180)

被引：27
作者：
Li, Jun
Chen, Stephanie Y.
Li, James J.
Wang, Haixia
Hernandez, Andres S.
Tao, Shiwei
Musial, Christa M.
Qu, Fucheng
Swartz, Stephen
Chao, Sam T.
Flynn, Neil
Murphy, Brian J.
Slusarchyk, Dorothy A.
Seethala, Ramakrishna
Yan, Mujing
Sleph, Paul
Grover, Gary
Smith, Mark A.
Beehler, Blake
Giupponi, Leah
Dickinson, Kenneth E.
Zhang, Hongjian
Humphreys, William G.
Patel, Bharat P.
Schwinden, Mark
Stouch, Terry
Cheng, Peter T. W.
Biller, Scott A.
Ewing, William R.
Gordon, David
Robl, Jeffrey A.
Tino, Joseph A.
机构：
[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Discovery Chem, Princeton, NJ 08543 USA
[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Metab Dis, Princeton, NJ 08543 USA
[3] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Metab & Pharmacokinet, Princeton, NJ 08543 USA
[4] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Proc Chem, Princeton, NJ 08543 USA
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 50卷 / 24期
关键词：
D O I：
10.1021/jm7010595
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development.
引用
收藏
页码：5890 / 5893
页数：4
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