Group 9 metal-based inhibitors of β-amyloid (1-40) fibrillation as potential therapeutic agents for Alzheimer's disease

被引：126

作者：

Man, Bradley Yat-Wah ^{[1
]}

Chan, Ho-Man ^{[1
]}

Leung, Chung-Hang ^{[2
]}

Chan, Daniel Shiu-Hin ^{[1
]}

Bai, Li-Ping ^{[2
]}

Jiang, Zhi-Hong ^{[2
]}

Li, Hung-Wing ^{[1
]}

Ma, Dik-Lung ^{[1
]}

机构：

[1] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

[2] Hong Kong Baptist Univ, Sch Chinese Med, Ctr Canc & Inflammat Res, Kowloon Tong, Hong Kong, Peoples R China

来源：

CHEMICAL SCIENCE | 2011年 / 2卷 / 05期

关键词：

PLATINUM(II) COMPLEXES; LUMINESCENT PROBES; PEPTIDE; AGGREGATION; RUTHENIUM; OLIGOMERS; DESIGN;

D O I：

10.1039/c0sc00636j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report here the first application of Group 9 metal complexes (i.e. iridium(III) and rhodium(III)) as inhibitors of amyloid fibrillogenesis and as luminescent probes for A beta(1-40) peptide. These complexes contained aromatic co-ligands to interact with the hydrophobic residues around the N-terminal domain of the A beta(1-40) peptide, as well as solvato co-ligands to allow coordinative bond formation with histidine residues. We demonstrate that these complexes could inhibit A beta(1-40) peptide aggregation in vitro, with potency superior to previous metal-based inhibitors reported. Furthermore, we have demonstrated the first example of luminescent detection of A beta(1-40) peptides by transition metal complexes.

引用

页码：917 / 921

页数：5

共 38 条

[1] METAL-COMPOUNDS IN THERAPY AND DIAGNOSIS [J].

ABRAMS, MJ ;

MURRER, BA .

SCIENCE, 1993, 261 (5122) :725-730

[2] Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence [J].

Ban, T ;

Hamada, D ;

Hasegawa, K ;

Naiki, H ;

Goto, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :16462-16465

[3] Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's disease [J].

Barnham, Kevin J. ;

Kenche, Vijaya B. ;

Ciccotosto, Giuseppe D. ;

Smith, David P. ;

Tew, Deborah J. ;

Liu, Xiang ;

Perez, Keyla ;

Cranston, Greg A. ;

Johanssen, Timothy J. ;

Volitakis, Irene ;

Bush, Ashley I. ;

Masters, Colin L. ;

White, Anthony R. ;

Smith, Jeffrey P. ;

Cherny, Robert A. ;

Cappai, Roberto .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (19) :6813-6818

[4] Study of the non-covalent interaction between amyloid-β-peptide and melatonin using electrospray ionization mass spectrometry [J].

Bazoti, FN ;

Tsarbopoulos, A ;

Markides, KE ;

Bergquist, J .

JOURNAL OF MASS SPECTROMETRY, 2005, 40 (02) :182-192

[5] New trends for metal complexes with anticancer activity [J].

Bruijnincx, Pieter C. A. ;

Sadler, Peter J. .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2008, 12 (02) :197-206

[6] CONTROLLING PLATINUM, RUTHENIUM, AND OSMIUM REACTIVITY FOR ANTICANCER DRUG DESIGN [J].

Bruijnincx, Pieter C. A. ;

Sadler, Peter J. .

ADVANCES IN INORGANIC CHEMISTRY, VOL 61: METAL ION CONTROLLED REACTIVITY, 2009, 61 :1-62

[7] Inhibition of Amyloid β Protein Fibrillation by Polymeric Nanoparticles [J].

Cabaleiro-Lago, Celia ;

Quinlan-Pluck, Fiona ;

Lynch, Iseult ;

Lindman, Stina ;

Minogue, Aedin M. ;

Thulin, Eva ;

Walsh, Dominic M. ;

Dawson, Kenneth A. ;

Linse, Sara .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (46) :15437-15443

[8] Alzheimer's disease: strategies for disease modification [J].

Citron, Martin .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (05) :387-398

[9] Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives [J].

Cohen, T ;

Frydman-Marom, A ;

Rechter, M ;

Gazit, E .

BIOCHEMISTRY, 2006, 45 (15) :4727-4735

[10] Cysteine proteases as targets for metal-based drugs [J].

Fricker, Simon P. .

METALLOMICS, 2010, 2 (06) :366-377

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