Genome editing comes of age

被引：62

作者：

Kim, Jin-Soo ^{[1
,2
]}

机构：

[1] Inst for Basic Sci Korea, Ctr Genome Engn, Seoul, South Korea

[2] Seoul Natl Univ, Dept Chem, Seoul, South Korea

来源：

NATURE PROTOCOLS | 2016年 / 11卷 / 09期

关键词：

ZINC-FINGER NUCLEASES; CRISPR-CAS SYSTEM; RNA-GUIDED ENDONUCLEASES; DNA-BINDING SPECIFICITY; DOUBLE-STRAND BREAKS; OFF-TARGET ACTIVITY; HUMAN-CELLS; GENE KNOCKOUT; RESTRICTION-ENDONUCLEASE; CAENORHABDITIS-ELEGANS;

D O I：

10.1038/nprot.2016.104

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome editing harnesses programmable nucleases to cut and paste genetic information in a targeted manner in living cells and organisms. Here, I review the development of programmable nucleases, including zinc finger nucleases (ZFNs), TAL (transcription-activator-like) effector nucleases (TALENs) and CRISPR (cluster of regularly interspaced palindromic repeats)-Cas9 (CRISPR-associated protein 9) RNA-guided endonucleases (RGENs). I specifically highlight the key advances that set the foundation for the rapid and widespread implementation of CRISPR-Cas9 genome editing approaches that has revolutionized the field.

引用

页码：1573 / 1578

页数：6

共 89 条

[51] Rapid "Open-Source" engineering of customized zinc-finger nucleases for highly efficient gene modification [J].

Maeder, Morgan L. ;

Thibodeau-Beganny, Stacey ;

Osiak, Anna ;

Wright, David A. ;

Anthony, Reshma M. ;

Eichtinger, Magdalena ;

Jiang, Tao ;

Foley, Jonathan E. ;

Winfrey, Ronnie J. ;

Townsend, Jeffrey A. ;

Unger-Wallace, Erica ;

Sander, Jeffry D. ;

Mueller-Lerch, Felix ;

Fu, Fengli ;

Pearlberg, Joseph ;

Goebel, Carl ;

Dassie, Justin P. ;

Pruett-Miller, Shondra M. ;

Porteus, Matthew H. ;

Sgroi, Dennis C. ;

Iafrate, A. John ;

Dobbs, Drena ;

McCray, Paul B., Jr. ;

Cathomen, Toni ;

Voytas, Daniel F. ;

Joung, J. Keith .

MOLECULAR CELL, 2008, 31 (02) :294-301

[52] CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering [J].

Mali, Prashant ;

Aach, John ;

Stranges, P. Benjamin ;

Esvelt, Kevin M. ;

Moosburner, Mark ;

Kosuri, Sriram ;

Yang, Luhan ;

Church, George M. .

NATURE BIOTECHNOLOGY, 2013, 31 (09) :833-+

[53] RNA-Guided Human Genome Engineering via Cas9 [J].

Mali, Prashant ;

Yang, Luhan ;

Esvelt, Kevin M. ;

Aach, John ;

Guell, Marc ;

DiCarlo, James E. ;

Norville, Julie E. ;

Church, George M. .

SCIENCE, 2013, 339 (6121) :823-826

[54] Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases [J].

Meng, Xiangdong ;

Noyes, Marcus B. ;

Zhu, Lihua J. ;

Lawson, Nathan D. ;

Wolfe, Scot A. .

NATURE BIOTECHNOLOGY, 2008, 26 (06) :695-701

[55] An improved zinc-finger nuclease architecture for highly specific genome editing [J].

Miller, Jeffrey C. ;

Holmes, Michael C. ;

Wang, Jianbin ;

Guschin, Dmitry Y. ;

Lee, Ya-Li ;

Rupniewski, Igor ;

Beausejour, Christian M. ;

Waite, Adam J. ;

Wang, Nathaniel S. ;

Kim, Kenneth A. ;

Gregory, Philip D. ;

Pabo, Carl O. ;

Rebar, Edward J. .

NATURE BIOTECHNOLOGY, 2007, 25 (07) :778-785

[56] A TALE nuclease architecture for efficient genome editing [J].

Miller, Jeffrey C. ;

Tan, Siyuan ;

Qiao, Guijuan ;

Barlow, Kyle A. ;

Wang, Jianbin ;

Xia, Danny F. ;

Meng, Xiangdong ;

Paschon, David E. ;

Leung, Elo ;

Hinkley, Sarah J. ;

Dulay, Gladys P. ;

Hua, Kevin L. ;

Ankoudinova, Irina ;

Cost, Gregory J. ;

Urnov, Fyodor D. ;

Zhang, H. Steve ;

Holmes, Michael C. ;

Zhang, Lei ;

Gregory, Philip D. ;

Rebar, Edward J. .

NATURE BIOTECHNOLOGY, 2011, 29 (02) :143-U149

[57] Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells [J].

Morton, Jason ;

Davis, M. Wayne ;

Jorgensen, Erik M. ;

Carroll, Dana .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (44) :16370-16375

[58] A Simple Cipher Governs DNA Recognition by TAL Effectors [J].

Moscou, Matthew J. ;

Bogdanove, Adam J. .

SCIENCE, 2009, 326 (5959) :1501-1501

[59] Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9 [J].

Park, Chul-Yong ;

Kim, Duk Hyoung ;

Son, Jeong Sang ;

Sung, Jin Jea ;

Lee, Jaehun ;

Bae, Sangsu ;

Kim, Jong-Hoon ;

Kim, Dong-Wook ;

Kim, Jin-Soo .

CELL STEM CELL, 2015, 17 (02) :213-220

[60] Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs [J].

Park, Chul-Yong ;

Kim, Jungeun ;

Kweon, Jiyeon ;

Son, Jeong Sang ;

Lee, Jae Souk ;

Yoo, Jeong-Eun ;

Cho, Sung-Rae ;

Kim, Jong-Hoon ;

Kim, Jin-Soo ;

Kim, Dong-Wook .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (25) :9253-9258

← 1 2 3 4 5 6 7 8 9 →