Chemokines and Chemokine Receptors in the Development of Lupus Nephritis

被引：45

作者：

Liao, Xiaofeng ^{[1
]}

Pirapakaran, Tharshikha ^{[1
]}

Luo, Xin M. ^{[1
]}

机构：

[1] Virginia Polytech Inst & State Univ, Virginia Maryland Coll Vet Med, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA

来源：

MEDIATORS OF INFLAMMATION | 2016年 / 2016卷

关键词：

MONOCYTE CHEMOATTRACTANT PROTEIN-1; REGULATORY T-CELLS; B-CELLS; DENDRITIC CELLS; MURINE LUPUS; MESANGIAL CELLS; GENE-EXPRESSION; INTERSTITIAL INFLAMMATION; FRACTALKINE EXPRESSION; IMMUNE-RESPONSES;

D O I：

10.1155/2016/6012715

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lupus nephritis (LN) is a major cause of morbidity and mortality in the patients with systemic lupus erythematosus (SLE), an autoimmune disease with damage to multiple organs. Leukocyte recruitment into the inflamed kidney is a critical step to promote LN progression, and the chemokine/chemokine receptor system is necessary for leukocyte recruitment. In this review, we summarize recent studies on the roles of chemokines and chemokine receptors in the development of LN and discuss the potential and hurdles of developing novel, chemokine-based drugs to treat LN.

引用

页数：15

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