The effects of high doses of vitamin D on the composition of the gut microbiome of adolescent girls

被引：23

作者：

Tabatabaeizadeh, Seyed-Amir ^{[1
]}

Fazeli, Mostafa ^{[2
]}

Meshkat, Zahra ^{[3
]}

Khodashenas, Ezzat ^{[4
]}

Esmaeili, Habibollah ^{[5
,6
]}

Mazloum, Seyedreza ^{[7
,8
]}

Ferns, Gordon A. ^{[9
]}

Abdizadeh, Mojtaba Fattahi ^{[10
]}

Ghayour-Mobarhan, Majid ^{[11
]}

机构：

[1] Gonabad Univ Med Sci, Social Dev & Hlth Promot Res Ctr, Sch Med, Nutr & Biochem Dept, Gonabad, Iran

[2] Mashhad Univ Med Sci, Sch Med, Genet & Mol Med Dept, Mashhad, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Antimicrobial Resistance Res Ctr, Mashhad, Razavi Khorasan, Iran

[4] Mashhad Univ Med Sci, Sch Med, Dept Pediat, Mashhad, Razavi Khorasan, Iran

[5] Mashhad Univ Med Sci, Sch Hlth, Dept Biostat, Mashhad, Razavi Khorasan, Iran

[6] Mashhad Univ Med Sci, Sch Hlth, Dept Epidemiol, Mashhad, Razavi Khorasan, Iran

[7] Mashhad Univ Med Sci, Fac Member Nursing, Evidence Based Care Res Ctr, Mashhad, Razavi Khorasan, Iran

[8] Mashhad Univ Med Sci, Midwifery Sch, Mashhad, Razavi Khorasan, Iran

[9] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England

[10] Sabzevar Univ Med Sci, Fac Med, Dept Microbiol, Sabzevar, Iran

[11] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Mashhad, Razavi Khorasan, Iran

来源：

CLINICAL NUTRITION ESPEN | 2020年 / 35卷

关键词：

Vitamin D; Microbiome; Adolescents; Inflammatory bowel disease; ESCHERICHIA-COLI; D DEFICIENCY; QUANTIFICATION; INFLAMMATION; ASSOCIATION; NEUTROPHIL; SAMPLES; HEALTH; SCORE; SPP;

D O I：

10.1016/j.clnesp.2019.10.020

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Animal studies suggest that vitamin D can change the gut microbiome. The primary aim of this study was to evaluate the effect of a high dose supplementation of vitamin D on the composition of the gut microbiome. Methods: After DNA extraction, TaqMan assays were used for the quantitation of selected microbiome in the feces of 50 adolescent girls before and after vitamin D supplementation. Results: The expression fold changes for Enterococcus, Bifidobacterium, Lactobacillus, Bacteroidetes and Firmicutes were; 1.05, 1.20, 0.76, 0.28 and 1.50 respectively. Bacteroidetes and Lactobacillus fell by 72% (P < 0.0001) and 24% (P = 0.006) respectively, whilst Firmicutes and Bifidobacterium were increased by 1.5 (P < 0.0001), 1.2 (P < 0.0001) fold after supplementation. Conclusion: Our results suggested that a high dose supplementation of vitamin D alter the human gut microbiome composition. Future studies are required for a better understanding of the mechanisms by which vitamin D affects the gut microbiome. (c) 2019 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

引用

页码：103 / 108

页数：6

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