Static and Dynamic Stereochemistry of Chiral Ln DOTA Analogues

被引：20
作者：
Di Bari, Lorenzo [1 ]
Salvadori, Piero [1 ]
机构：
[1] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy
来源：
CHEMPHYSCHEM | 2011年 / 12卷 / 08期
关键词：
chirality; circular dichroism; conformation; lanthanides; MRI contrast agents; MRI CONTRAST AGENTS; LANTHANIDE TETRAAMIDE COMPLEXES; INFRARED CIRCULAR-DICHROISM; ALPHA-AMINO-ACIDS; AQUEOUS-SOLUTION; 1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC ACID; CONFORMATIONAL MOBILITY; BIOMEDICAL APPLICATIONS; ALKYL SUBSTITUTION; DIAQUA-YTTERBIUM;
D O I：
10.1002/cphc.201100017
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Ln DOTA derivatives (DOTA= 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) are known to undergo relevant stereoisomeric equilibria in solution, which greatly modulate their chemical as well as their magnetic and optical properties. The subject is reviewed in terms of classical stereochemical description, with reference to conformational enthalpies. Yb is taken as the reference element because of its unique spectroscopic properties, namely, a small contact contribution to the paramagnetic shift and an intense near-infrared electronic circular dichroism, endowed with an easily recognizable fine structure.
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收藏
页码：1490 / 1497
页数：8
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