Advances and Future Perspectives in 4D Bioprinting

被引：176

作者：

Ashammakhi, Nureddin ^{[1
,2
,3
]}

Ahadian, Samad ^{[1
,2
]}

Fan Zengjie ^{[1
,2
,4
]}

Suthiwanich, Kasinan ^{[1
,2
,5
]}

Lorestani, Farnaz ^{[1
,2
,6
,7
]}

Orive, Gorka ^{[8
,9
,10
]}

Ostrovidov, Serge ^{[1
,2
]}

Khademhosseini, Ali ^{[1
,2
,11
,12
,13
,14
]}

机构：

[1] Univ Calif Los Angeles, C MIT, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[3] Oulu Univ, Dept Surg, Div Plast Surg, Oulu 8000, Finland

[4] Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China

[5] Tokyo Inst Technol, Dept Mat Sci & Engn, Sch Mat & Chem Technol, Tokyo 1528550, Japan

[6] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia

[7] Univ Malaya, Ctr Ion Liquids UMCiL, Kuala Lumpur 50603, Malaysia

[8] Univ Basque Country, UPV EHU, Fac Pharm, Vitoria 48940, Spain

[9] CIBER BBN, Networking Biomed Res Ctr Bioengn Biomat & Nanome, Vitoria 28029, Spain

[10] Univ Basque Country, Fdn Eduardo Anitua, Univ Inst Regenerat Med & Oral Implantol UIRMI, Vitoria 48940, Spain

[11] Univ Calif Los Angeles, Dept Radiol Sci, Los Angeles, CA 90095 USA

[12] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA

[13] King Abdulaziz Univ, Ctr Nanotechnol, Dept Phys, Jeddah 21589, Saudi Arabia

[14] Konkuk Univ, Dept Bioind Technol, Coll Anim Biosci & Technol, Seoul 05029, South Korea

来源：

BIOTECHNOLOGY JOURNAL | 2018年 / 13卷 / 12期

基金：

美国国家卫生研究院;

关键词：

4D bioprinting; additive manufacturing; bioinks; stimuli-responsive biomaterials; tissue engineering; DRUG-DELIVERY; ELECTRICAL-STIMULATION; CARBON NANOTUBES; ON-DEMAND; HYDROGELS; GRAPHENE; POLYMER; CELLS; PH; DIFFERENTIATION;

D O I：

10.1002/biot.201800148

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Three-dimensionally printed constructs are static and do not recapitulate the dynamic nature of tissues. Four-dimensional (4D) bioprinting has emerged to include conformational changes in printed structures in a predetermined fashion using stimuli-responsive biomaterials and/or cells. The ability to make such dynamic constructs would enable an individual to fabricate tissue structures that can undergo morphological changes. Furthermore, other fields (bioactuation, biorobotics, and biosensing) will benefit from developments in 4D bioprinting. Here, the authors discuss stimuli-responsive biomaterials as potential bioinks for 4D bioprinting. Natural cell forces can also be incorporated into 4D bioprinted structures. The authors introduce mathematical modeling to predict the transition and final state of 4D printed constructs. Different potential applications of 4D bioprinting are also described. Finally, the authors highlight future perspectives for this emerging technology in biomedicine.

引用

页数：12

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