Emerging Strategies for Treating Brain Metastases from Breast Cancer

被引：123

作者：

Kodack, David P. ^{[1
,2
]}

Askoxylakis, Vasileios ^{[1
,2
]}

Ferraro, Gino B. ^{[1
,2
]}

Fukumura, Dai ^{[1
,2
]}

Jain, Rakesh K. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Edwin L Steele Lab, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

CANCER CELL | 2015年 / 27卷 / 02期

关键词：

NERVOUS-SYSTEM METASTASES; PROPHYLACTIC CRANIAL IRRADIATION; TUMOR-CELLS; TRASTUZUMAB EMTANSINE; KINASE INHIBITOR; OPEN-LABEL; PHASE-II; SURVIVAL; GROWTH; LAPATINIB;

D O I：

10.1016/j.ccell.2015.01.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain metastasis is an end stage in breast cancer progression. Traditional treatment options have minimal efficacy, and overall survival is on the order of months. The incidence of brain metastatic disease is increasing with the improved management of systemic disease and prolongation of survival. Unfortunately, the targeted therapies that control systemic disease have diminished efficacy against brain lesions. There are reasons to be optimistic, however, as emerging therapies have shown promise in preclinical and early clinical settings. This review discusses recent advances in breast cancer brain metastasis therapy and potential approaches for successful treatment.

引用

页码：163 / 175

页数：13

共 93 条

[1] P-glycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model [J].

Adkins, Chris E. ;

Mittapalli, Rajendar K. ;

Manda, Vamshi K. ;

Nounou, Mohamed I. ;

Mohammad, Afroz S. ;

Terrell, Tori B. ;

Bohn, Kaci A. ;

Yasemin, Celik ;

Grothe, Tiffany R. ;

Lockman, Julie A. ;

Lockman, Paul R. .

FRONTIERS IN PHARMACOLOGY, 2013, 4

[2] Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises [J].

Armulik, Annika ;

Genove, Guillem ;

Betsholtz, Christer .

DEVELOPMENTAL CELL, 2011, 21 (02) :193-215

[3] Metastatic breast cancer subtypes and central nervous system metastases [J].

Aversa, C. ;

Rossi, V. ;

Geuna, E. ;

Martinello, R. ;

Milani, A. ;

Redana, S. ;

Valabrega, G. ;

Aglietta, M. ;

Montemurro, F. .

BREAST, 2014, 23 (05) :623-628

[4] Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain [J].

Avraham, Hava Karsenty ;

Jiang, Shuxian ;

Fu, Yigong ;

Nakshatri, Harikrishna ;

Ovadia, Haim ;

Avraham, Shalom .

JOURNAL OF PATHOLOGY, 2014, 232 (03) :369-381

[5] Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study [J].

Bachelot, Thomas ;

Romieu, Gilles ;

Campone, Mario ;

Dieras, Veronique ;

Cropet, Claire ;

Dalenc, Florence ;

Jimenez, Marta ;

Le Rhun, Emilie ;

Pierga, Jean-Yves ;

Goncalves, Anthony ;

Leheurteur, Marianne ;

Domont, Julien ;

Gutierrez, Maya ;

Cure, Herve ;

Ferrero, Jean-Marc ;

Labbe-Devilliers, Catherine .

LANCET ONCOLOGY, 2013, 14 (01) :64-71

[6] Trastuzumab prolongs overall survival in patients with brain metastases from Her2 positive breast cancer [J].

Bartsch, Rupert ;

Rottenfusser, Andrea ;

Wenzel, Catharina ;

Dieckmann, Karin ;

Pluschnig, Ursula ;

Altorjai, Gabriela ;

Rudas, Margaretha ;

Mader, Robert M. ;

Poetter, Richard ;

Zielinski, Christoph C. ;

Steger, Guenther G. .

JOURNAL OF NEURO-ONCOLOGY, 2007, 85 (03) :311-317

[7] Breast cancer brain metastases responding to primary systemic therapy with T-DM1 [J].

Bartsch, Rupert ;

Berghoff, Anna S. ;

Preusser, Matthias .

JOURNAL OF NEURO-ONCOLOGY, 2014, 116 (01) :205-206

[8] Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts [J].

Baschnagel, Andrew ;

Russo, Andrea ;

Burgan, William E. ;

Carter, Donna ;

Beam, Katie ;

Palmieri, Diane ;

Steeg, Patricia S. ;

Tofilon, Philip ;

Camphausen, Kevin .

MOLECULAR CANCER THERAPEUTICS, 2009, 8 (06) :1589-1595

[9] Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging [J].

Bell, Robert D. ;

Winkler, Ethan A. ;

Sagare, Abhay P. ;

Singh, Itender ;

LaRue, Barb ;

Deane, Rashid ;

Zlokovic, Berislav V. .

NEURON, 2010, 68 (03) :409-427

[10] Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma [J].

Bendell, JC ;

Domchek, SM ;

Burstein, HJ ;

Harris, L ;

Younger, J ;

Kuter, I ;

Bunnell, C ;

Rue, M ;

Gelman, R ;

Winer, E .

CANCER, 2003, 97 (12) :2972-2977

← 1 2 3 4 5 6 7 8 9 10 →