A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12

被引：49
作者：
Shink, E
Morissette, J
Sherrington, R
Barden, N
机构：
[1] CHU Laval, Res Ctr, Quebec City, PQ G1V 4G2, Canada
[2] Univ Laval, Quebec City, PQ, Canada
[3] Axys Pharmaceut Inc, San Francisco, CA USA
来源：
MOLECULAR PSYCHIATRY | 2005年 / 10卷 / 06期
基金：
加拿大健康研究院;
关键词：
chromosome; 12; complex disease; genome scan; linkage analysis; manic depression;
D O I：
10.1038/sj.mp.4001601
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Our previous results pointed to a putative gene for susceptibility to bipolar affective disorder located on the chromosomal region 12q23 - q24 that segregated in the Saguenay-Lac-St-Jean population of Quebec. We report here results from a second genome-wide scan based on the analysis of 380 polymorphic microsatellite markers. For the purpose of this analysis, an additional 18 families were recruited from the Saguenay-Lac-St-Jean region and pooled to our previous sample to improve its statistical power, giving a total of 394 sampled individuals. This work confirms the presence of a susceptibility locus for affective disorder on chromosome 12q24 with parametric LOD score value of 3.35 at D12S378 when pedigrees were broken into nuclear families and analysed under a recessive segregation model. This result was supported by neighbouring markers and by a LOD score value of 5.05 at D12S378 under model-free analysis. Other regions of lower interest were indicated on chromosomes 2, 5, 7, 9, 10, 17 and 20.
引用
收藏
页码：545 / 552
页数：8
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