A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12

被引：49
作者：
Shink, E
Morissette, J
Sherrington, R
Barden, N
机构：
[1] CHU Laval, Res Ctr, Quebec City, PQ G1V 4G2, Canada
[2] Univ Laval, Quebec City, PQ, Canada
[3] Axys Pharmaceut Inc, San Francisco, CA USA
来源：
MOLECULAR PSYCHIATRY | 2005年 / 10卷 / 06期
基金：
加拿大健康研究院;
关键词：
chromosome; 12; complex disease; genome scan; linkage analysis; manic depression;
D O I：
10.1038/sj.mp.4001601
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Our previous results pointed to a putative gene for susceptibility to bipolar affective disorder located on the chromosomal region 12q23 - q24 that segregated in the Saguenay-Lac-St-Jean population of Quebec. We report here results from a second genome-wide scan based on the analysis of 380 polymorphic microsatellite markers. For the purpose of this analysis, an additional 18 families were recruited from the Saguenay-Lac-St-Jean region and pooled to our previous sample to improve its statistical power, giving a total of 394 sampled individuals. This work confirms the presence of a susceptibility locus for affective disorder on chromosome 12q24 with parametric LOD score value of 3.35 at D12S378 when pedigrees were broken into nuclear families and analysed under a recessive segregation model. This result was supported by neighbouring markers and by a LOD score value of 5.05 at D12S378 under model-free analysis. Other regions of lower interest were indicated on chromosomes 2, 5, 7, 9, 10, 17 and 20.
引用
收藏
页码：545 / 552
页数：8
相关论文
共 75 条
[1]   Predisposition locus for major depression at chromosome 12q22-12q23.2 [J].
Abkevich, V ;
Camp, NJ ;
Hensel, CH ;
Neff, CD ;
Russell, DL ;
Hughes, DC ;
Plenk, AM ;
Lowry, MR ;
Richards, RL ;
Carter, C ;
Frech, GC ;
Stone, S ;
Rowe, K ;
Chau, CA ;
Cortado, K ;
Hunt, A ;
Luce, K ;
O'Neil, G ;
Poarch, J ;
Potter, J ;
Poulsen, GH ;
Saxton, H ;
Bernat-Sestak, M ;
Thompson, V ;
Gutin, A ;
Skolnick, MH ;
Shattuck, D ;
Cannon-Albright, L .
AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (06) :1271-1281
[2]   Possible evidence for a common risk locus for bipolar affective disorder and schizophrenia on chromosome 4p16 in patients from the Faroe Islands [J].
Als, TD ;
Dahl, HA ;
Flint, TJ ;
Wang, AG ;
Vang, M ;
Mors, O ;
Kruse, TA ;
Ewald, H .
MOLECULAR PSYCHIATRY, 2004, 9 (01) :93-98
[3]   Hyperekplexia: Abnormal startle response due to glycine receptor mutations [J].
Andrew, M ;
Owen, MJ .
BRITISH JOURNAL OF PSYCHIATRY, 1997, 170 :106-108
[4]   A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders [J].
Anguelova, M ;
Benkelfat, C ;
Turecki, G .
MOLECULAR PSYCHIATRY, 2003, 8 (06) :574-591
[5]   A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder [J].
Asherson, P ;
Mant, R ;
Williams, N ;
Cardno, A ;
Jones, L ;
Murphy, K ;
Collier, DA ;
Nanko, S ;
Craddock, N ;
Morris, S ;
Muir, W ;
Blackwood, B ;
McGuffin, P ;
Owen, MJ .
MOLECULAR PSYCHIATRY, 1998, 3 (04) :310-320
[6]   CHROMOSOME-18 DNA MARKERS AND MANIC-DEPRESSIVE ILLNESS - EVIDENCE FOR A SUSCEPTIBILITY GENE [J].
BERRETTINI, WH ;
FERRARO, TN ;
GOLDIN, LR ;
WEEKS, DE ;
DETERAWADLEIGH, S ;
NURNBERGER, JI ;
GERSHON, ES .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :5918-5921
[7]   A locus for bipolar affective disorder on chromosome 4p [J].
Blackwood, DHR ;
He, L ;
Morris, SW ;
McLean, A ;
Whitton, C ;
Thomson, M ;
Walker, MT ;
Woodburn, K ;
Sharp, CM ;
Wright, AF ;
Shibasaki, Y ;
StClair, DM ;
Porteous, DJ ;
Muir, WJ .
NATURE GENETICS, 1996, 12 (04) :427-430
[8]  
COTTINGHAM RW, 1993, AM J HUM GENET, V53, P252
[9]   FAMILIAL COSEGREGATION OF MAJOR AFFECTIVE-DISORDER AND DARIERS-DISEASE (KERATOSIS-FOLLICULARIS) [J].
CRADDOCK, N ;
OWEN, M ;
BURGE, S ;
KURIAN, B ;
THOMAS, P ;
MCGUFFIN, P .
BRITISH JOURNAL OF PSYCHIATRY, 1994, 164 :355-358
[10]   Genetics of bipolar disorder [J].
Craddock, N ;
Jones, I .
JOURNAL OF MEDICAL GENETICS, 1999, 36 (08) :585-594
12345678