RETRACTED: Isolation of optically active nevirapine, a dipyridodiazepinone metabolite from the seeds of Cleome viscosa (Retracted article. See vol. 67, pg. 4291, 2011)

被引：7

作者：

Chattopadhyay, Sunil K. ^{[1
]}

Chatterjee, Arnab ^{[1
]}

Tandon, Sudeep ^{[1
]}

Maulik, Prakas R. ^{[2
]}

Kant, Ruchir ^{[2
]}

机构：

[1] Cent Inst Med & Aromat Plants CSIR, Proc Chem & Chem Engn Dept, Lucknow 226015, Uttar Pradesh, India

[2] Cent Drug Res Inst CSIR, Mol & Struct Biol Div, Lucknow 226001, Uttar Pradesh, India

来源：

TETRAHEDRON | 2011年 / 67卷 / 02期

关键词：

Cleome viscosa; Nevirapine; Dipyridodiazepinone; Secondary metabolite; Optically active; HIV-1; REVERSE-TRANSCRIPTASE;

D O I：

10.1016/j.tet.2010.11.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The optically active nevirapine, a natural analogue of the previously designed and synthesized optically inactive nevirapine, a non-nucleoside inhibitor of HIV-1 reverse transcriptase, has been isolated and fully characterized from the seeds of Cleome viscosa. The structure of natural nevirapine has been confirmed by X-ray crystallography. It is an interesting discovery to find out that optically inactive nevirapine was designed and synthesized before the isolation of optically active nevirapine from the seeds of C. viscosa. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：452 / 454

页数：3

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