Cyclophilin A - Promising New Target in Cardiovascular Therapy

被引：74
作者：
Satoh, Kimio [1 ,2 ,3 ]
Shimokawa, Hiroaki
Berk, Bradford C. [2 ,3 ]
机构：
[1] Tohoku Univ, Grad Sch Med, Dept Cardiovasc Med, Aoba Ku, Sendai, Miyagi 9808574, Japan
[2] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA
[3] Univ Rochester, Sch Med & Dent, Inst Med, Rochester, NY USA
来源：
CIRCULATION JOURNAL | 2010年 / 74卷 / 11期
关键词：
Immunophilin; Matrix metalloproteinase; Reactive oxygen species; Remodeling; Vasculature; INDUCED PULMONARY-HYPERTENSION; ABDOMINAL-AORTIC-ANEURYSM; SMOOTH-MUSCLE-CELLS; METALLOPROTEINASE INDUCER EMMPRIN; II-INDUCED ATHEROSCLEROSIS; RHO-KINASE INHIBITOR; OXIDATIVE STRESS; BINDING-PROTEIN; ENDOTHELIAL DYSFUNCTION; ERYTHROPOIETIN RECEPTOR;
D O I：
10.1253/circj.CJ-10-0904
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms. (Circ J 2010; 74: 2249-2256)
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收藏
页码：2249 / 2256
页数：8
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