Palladium-catalyzed decarboxylative C3-acylation of benzofurans and benzothiophenes with α-oxocarboxylic acids via direct sp2 C-H bond activation

被引：24

作者：

Gong, Wei-Jie ^{[1
]}

Liu, De-Xian ^{[1
]}

Li, Fei-Long ^{[1
]}

Gao, Jun ^{[1
]}

Li, Hong-Xi ^{[1
]}

Lang, Jian-Ping ^{[1
,2
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 210032, Peoples R China

来源：

TETRAHEDRON | 2015年 / 71卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Decarboxylation; Palladium(II); Benzofuran; Benzothiophene; Acylation; alpha-Oxocarboxylic acids; ORTHO-ACYLATION; DIRECT ARYLATION; FUNCTIONALIZATION; MARINOPYRROLE; THIOPHENES; INHIBITOR; INDOLES; KETONES; ARENES; POTENT;

D O I：

10.1016/j.tet.2014.12.095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient approach to decarboxylative C3-acylation of benzothiophenes or benzofurans with alpha-oxocarboxylic acids via palladium-catalyzed C-H bond activation was developed. This method was compatible with a variety of functional groups and provided an attractive route to 3-acylbenzothiophenes and 3-acylbenzofurans in good to high yields. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：1269 / 1275

页数：7

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