Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics

被引：23

作者：

Cabrera, Claudia P. ^{[1
,2
]}

Ng, Fu Liang ^{[1
]}

Warren, Helen R. ^{[1
,2
]}

Barnes, Michael R. ^{[1
,2
]}

Munroe, Patricia B. ^{[1
,2
]}

Caulfield, Mark J. ^{[1
,2
]}

机构：

[1] Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, Dept Clin Pharmacol, London, England

[2] Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, London, England

来源：

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE | 2015年 / 7卷 / 02期

关键词：

INFLUENCING ANTIHYPERTENSIVE RESPONSE; BLOOD-PRESSURE TRAITS; NITRIC-OXIDE SYNTHASE; TAMM-HORSFALL PROTEIN; CARDIOVASCULAR-DISEASE; GENETIC-VARIANTS; PERSONALIZED MEDICINE; SUSCEPTIBILITY LOCI; COMMON VARIANTS; CANDIDATE GENE;

D O I：

10.1002/wsbm.1290

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hypertension is a major risk factor for global mortality. Recent genome-wide association studies (GWAS) have led to successful identification of many genetic loci influencing blood pressure, although these studies account for less than 5% of heritability. While genetic discovery efforts continue, it is timely to pause and reflect on what information has been gained to date from reported loci. Knowledge from GWAS findings inform our understanding of the pathways and pleiotropy underpinning hypertension and aid in the identification of potential druggable targets. By reviewing blood pressure loci we aim to determine how much potential the current observations have for future clinical utility. (C) 2015 Wiley Periodicals, Inc.

引用

页码：73 / 90

页数：18

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