New cassane butenolide hemiketal diterpenes from the marine creeper Caesalpinia bonduc and their antiproliferative activity

被引：36
|
作者：
Yadav, Prem P. [1 ]
Arora, Ashish
Bid, Hemant K.
Konwar, Ritu R.
Kanojiya, Sanjeev
机构：
[1] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Mol & Struct Biol Div, Lucknow 226001, Uttar Pradesh, India
[3] Cent Drug Res Inst, Div Endocrinol, Lucknow 226001, Uttar Pradesh, India
[4] Cent Drug Res Inst, Sophisticated Analyt Instrument Facil, Lucknow 226001, Uttar Pradesh, India
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 40期
关键词：
D O I：
10.1016/j.tetlet.2007.07.206
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new cassane butenolides, caesalpinolide A (1) and B (2), epimeric at the hemiketal position were isolated from the marine creeper Caesalpinia bonduc. The structures were elucidated by the analysis of spectroscopic data and relative stereochemistry was assigned on the basis of ROESY correlations. Compounds I and 2 were found to inhibit MCF-7 breast cancer cell lines with IC50 values of (mu M) 12.8 and 6.1, respectively, along with the inhibition of endometrial and cervical cancer cell lines. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7194 / 7198
页数：5
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