3D printed microfluidic devices with integrated valves

被引：231

作者：

Rogers, Chad I. ^{[1
]}

Qaderi, Kamran ^{[2
]}

Woolley, Adam T. ^{[1
]}

Nordin, Gregory P. ^{[2
]}

机构：

[1] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

[2] Brigham Young Univ, Dept Elect & Comp Engn, Provo, UT 84602 USA

来源：

BIOMICROFLUIDICS | 2015年 / 9卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ON-A-CHIP; POLYETHYLENE-GLYCOL DIACRYLATE; ULTRASENSITIVE DETECTION; INFECTIOUS-DISEASES; CHEMICAL-SYNTHESIS; CANCER BIOMARKERS; LAB; POLY(DIMETHYLSILOXANE); REACTIONWARE; ADSORPTION;

D O I：

10.1063/1.4905840

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the successful fabrication and testing of 3D printed microfluidic devices with integrated membrane-based valves. Fabrication is performed with a low-cost commercially available stereolithographic 3D printer. Horizontal microfluidic channels with designed rectangular cross sectional dimensions as small as 350 mu m wide and 250 mu m tall are printed with 100% yield, as are cylindrical vertical microfluidic channels with 350 mu m designed (210 mu m actual) diameters. Based on our previous work [Rogers et al., Anal. Chem. 83, 6418 (2011)], we use a custom resin formulation tailored for low non-specific protein adsorption. Valves are fabricated with a membrane consisting of a single build layer. The fluid pressure required to open a closed valve is the same as the control pressure holding the valve closed. 3D printed valves are successfully demonstrated for up to 800 actuations. (c) 2015 AIP Publishing LLC.

引用

页数：9

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