Sonic Hedgehog pathway activity in prostate cancer

被引：13
作者：
Bragina, Olga [1 ]
Njunkova, Natalja [4 ]
Sergejeva, Svetlana [2 ]
Jarvekulg, Lilian [3 ,5 ]
Kogerman, Priit [1 ,3 ,5 ]
机构：
[1] Tallinn Univ Technol, Dept Oncol, Inst Clin Med, Tallinn, Estonia
[2] Tallinn Univ Technol, Dept Clin Med, Inst Clin Med, Tallinn, Estonia
[3] Tallinn Univ Technol, Dept Gene Technol, Div Mol Diagnost, Tallinn, Estonia
[4] Cent Lab Communicable Dis, Hlth Protect Inspectorate, Tallinn, Estonia
[5] Competence Ctr Canc Res, Tallinn, Estonia
来源：
ONCOLOGY LETTERS | 2010年 / 1卷 / 02期
基金：
英国惠康基金;
关键词：
transgenic adenocarcinoma of the mouse prostate; mice; immunohistochemistry; DOWN-REGULATION; KRUPPEL FAMILY; PROLIFERATION; EXPRESSION; INTERFERENCE; PROGRESSION; INHIBITION; ACTIVATION; PROMOTER; CELLS;
D O I：
10.3892/ol_00000057
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Abnormal activation of the Sonic hedgehog (Shh) signaling pathway has been demonstrated in a number of human tumors, including prostate cancer The study aimed to assess the activity of Shh pathway components (Shh, Gli1, Gli2 and Gli3), as well as the proliferation markers FoxAl and Notch1 during cancer progression in the transgenic adenocarcinoma of the mouse prostate (TRAMP) We evaluated changes in respective proteins by immunohistochemistry at three time points (12, 17 and 21 weeks of age) in the tissue of TRAMP and C57Bl/6 mice Moreover, the expression of mRNA of these proteins was assessed The present study shows a significant age-dependent increase in the number of Shh, Glil1, Gli3 and FoxAl-positive prostate cells and a decrease in Gli2-positive cells in TRAMP The study also supports the hypothesis that the development of prostate cancer and its metastasis is associated with activation of the Shh signaling pathway
引用
收藏
页码：319 / 325
页数：7
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