A turn-on fluorescent chemosensor for Zn2+ ion: X-ray structure and application in cell imaging study

被引：20

作者：

Ghosh, Koushik ^{[1
]}

Dey, Sudipto ^{[1
]}

Halder, Shibashis ^{[1
]}

Bhattacharjee, Aradhita ^{[1
]}

Rizzoli, Corrado ^{[2
]}

Roy, Partha ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Chem, Kolkata 700032, India

[2] Univ Parma, Dipartimento Chim, Parco Area Sci 17-A, I-43124 Parma, Italy

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2016年 / 1118卷

关键词：

Schiff-base; Fluorescence; Zinc sensor; X-ray crystal structure; DFT; Cell imaging; SENSITIVE SCHIFF-BASE; SELECTIVE DETECTION; CRYSTAL-STRUCTURES; ZINC; SENSOR; POTENTIALS; CHEMISTRY; CONTINUUM; MERCURY; COMPLEX;

D O I：

10.1016/j.molstruc.2016.04.006

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The selective fluorescence zinc(II) sensing properties of a Schiff-base compound, 2-methoxy-6-(2-morpholinoethyliminomethyl)phenol (HL) have been explored. The emission intensity of HL in the presence of one equivalent of Zn2+ ion increases by about 25 times. Several other metal ions, except Cd2+ and Ni2+, have not been able to increase the emission intensity of HL significantly. The quantum yield and life-time of HL have also been increased in the presence of Zn2+ ions. The enhancement in fluorescence intensity of HL is mainly due to the restriction of ESIPT, CHEF and PET on complex formation. HL forms a complex with Zn2+ in 1:1 ratio as evidenced by Job's plot analysis and X-ray single crystal structure determination. Some theoretical calculations have been performed to get a better view on the nature of the observed electronic transitions. The probe has been applied for imaging of DLD-1, human colorectal adenocarcinoma cell. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：325 / 334

页数：10

共 63 条

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