Early Lung Disease in Infants and Preschool Children with Cystic Fibrosis What Have We Learned and What Should We Do about It?

被引：102

作者：

Ranganathan, Sarath C. ^{[1
,2
,3
]}

Hall, Graham L. ^{[4
,5
,6
]}

Sly, Peter D. ^{[7
,8
]}

Stick, Stephen M. ^{[4
,5
,9
]}

Douglas, Tonia A. ^{[4
,7
]}

机构：

[1] Royal Childrens Hosp, Dept Resp Med, Melbourne, Vic, Australia

[2] Murdoch Childrens Res Inst, Infect & Immun, Melbourne, Vic, Australia

[3] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

[4] Telethon Kids Inst, Perth, WA, Australia

[5] Univ Western Australia, Ctr Child Hlth Res, Perth, WA, Australia

[6] Curtin Univ, Sch Physiotherapy & Exercise Sci, Perth, WA, Australia

[7] Childrens Hlth Queensland, Dept Resp & Sleep Med, South Brisbane, Qld, Australia

[8] Univ Queensland, Child Hlth Res Ctr, Brisbane, Qld, Australia

[9] Princess Margaret Hosp Children, Dept Resp Med, Perth, WA, Australia

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2017年 / 195卷 / 12期

关键词：

cystic fibrosis; early lung disease; newborn screening; early intervention; PSEUDOMONAS-AERUGINOSA ACQUISITION; YOUNG-CHILDREN; COMPUTED-TOMOGRAPHY; PULMONARY INFLAMMATION; AIRWAY INFLAMMATION; CLEARANCE INDEX; DORNASE-ALPHA; VENTILATION INHOMOGENEITY; BRONCHOALVEOLAR LAVAGE; RESPIRATORY-INFECTION;

D O I：

10.1164/rccm.201606-1107CI

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The past decade has seen significant advances in understanding of the pathogenesis and progression of lung disease in cystic fibrosis (CF). Pulmonary inflammation, infection, and structural lung damage manifest very early in life and are prevalent among preschool children and infants, often in the absence of symptoms or signs. Early childhood represents a pivotal period amenable to intervention strategies that could delay or prevent the onset of lung damage and alter the longer-term clinical trajectory for individuals with CF. This review summarizes what we have learned about early lung disease in children with CF and discusses the implications for future clinical practice and research.

引用

页码：1567 / 1575

页数：9

共 90 条

[41] Chest computed tomography: a validated surrogate endpoint of cystic fibrosis lung disease? [J].

Loeve, Martine ;

Krestin, Gabriel P. ;

Rosenfeld, Margaret ;

de Bruijne, Marleen ;

Stick, Stephen M. ;

Tiddens, Harm A. .

EUROPEAN RESPIRATORY JOURNAL, 2013, 42 (03) :844-857

[42] High-resolution computed tomography imaging of airway disease in infants with cystic fibrosis [J].

Martínez, TM ;

Llapur, CJ ;

Williams, TH ;

Coates, C ;

Gunderman, R ;

Cohen, MD ;

Howenstine, MS ;

Saba, O ;

Coxson, HO ;

Tepper, RS .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 172 (09) :1133-1138

[43] The nasal microbiota in infants with cystic fibrosis in the first year of life: a prospective cohort study [J].

Mika, Moana ;

Korten, Insa ;

Qi, Weihong ;

Regamey, Nicolas ;

Frey, Urs ;

Casaulta, Carmen ;

Latzin, Philipp ;

Hilty, Markus .

LANCET RESPIRATORY MEDICINE, 2016, 4 (08) :627-635

[44] Progression of early structural lung disease in young children with cystic fibrosis assessed using CT [J].

Mott, Lauren S. ;

Park, Judy ;

Murray, Conor P. ;

Gangell, Catherine L. ;

de Klerk, Nicholas H. ;

Robinson, Philip J. ;

Robertson, Colin F. ;

Ranganathan, Sarath C. ;

Sly, Peter D. ;

Stick, Stephen M. .

THORAX, 2012, 67 (06) :509-516

[45] Bronchiectasis in an asymptomatic infant with cystic fibrosis diagnosed following newborn screening [J].

Mott, Lauren S. ;

Gangell, Catherine L. ;

Murray, Conor P. ;

Stick, Stephen M. ;

Sly, Peter D. .

JOURNAL OF CYSTIC FIBROSIS, 2009, 8 (04) :285-287

[46] Use of computerized tomography and chest x-rays in evaluating efficacy of aerosolized recombinant human DNase in cystic fibrosis patients younger than age 5 years: A preliminary study [J].

Nasr, SZ ;

Kuhns, LR ;

Brown, RW ;

Hurwitz, ME ;

Sanders, GM ;

Strouse, PJ .

PEDIATRIC PULMONOLOGY, 2001, 31 (05) :377-382

[47] Lung Clearance Index and HRCT are complementary markers of lung abnormalities in young children with CF [J].

Owens, C. M. ;

Aurora, P. ;

Stanojevic, S. ;

Bush, A. ;

Wade, A. ;

Oliver, C. ;

Calder, A. ;

Price, J. ;

Carr, S. B. ;

Shankar, A. ;

Stocks, Janet .

THORAX, 2011, 66 (06) :481-488

[48] Infant care patterns at epidemiologic study of cystic fibrosis sites that achieve superior childhood lung function [J].

Padman, Raj ;

McColley, Susanna A. ;

Miller, Dave P. ;

Konstan, Michael W. ;

Morgan, Wayne J. ;

Schechter, Michael S. ;

Ren, Clement L. ;

Wagener, Jeffrey S. .

PEDIATRICS, 2007, 119 (03) :E531-E537

[49] Effect of treatment with dornase alpha on airway inflammation in patients with cystic fibrosis [J].

Paul, K ;

Rietschel, E ;

Ballmann, M ;

Griese, M ;

Worlitzsch, D ;

Shute, J ;

Chen, C ;

Schink, T ;

Döring, G ;

van Koningsbruggen, S ;

Wahn, U ;

Ratjen, F .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 169 (06) :719-725

[50] VENTILATORY FUNCTION IN INFANTS WITH CYSTIC FIBROSIS - PHYSIOLOGICAL ASSESSMENT OF INHALATION THERAPY [J].

PHELAN, PD ;

GRACEY, M ;

WILLIAMS, HE ;

ANDERSON, CM .

ARCHIVES OF DISEASE IN CHILDHOOD, 1969, 44 (235) :393-&

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