Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L.

被引：52

作者：

Ha, Manh Tuan ^{[1
,2
]}

Tran, Manh Hung ^{[1
]}

Ah, Kim Jeong ^{[3
]}

Jo, Kyung-Jin ^{[4
]}

Kim, Jaewang ^{[4
]}

Kim, Wook Dong

Cheon, Woo Jae ^{[5
]}

Woo, Mi Hee ^{[1
,5
]}

Ryu, Sung Ho ^{[4
]}

Min, Byung Sun ^{[1
]}

机构：

[1] Catholic Univ Daegu, Coll Pharm, Drug Res & Dev Ctr, Gyeongbuk 712702, South Korea

[2] Vietnam Acad Sci & Technol, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[3] Kyungpook Natl Univ, Coll Pharm, Taegu 702701, South Korea

[4] Pohang Univ Sci & Technol, Div Mol & Life Sci, Pohang, South Korea

[5] Gyeongsanbuk Do Forest Environm Res Inst, Gyeongju 780936, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 12期

关键词：

Morus alba; Moraceae; 2-Arylbenzofuran; Geranylated stilbene; Pancreatic lipase; CULTIVATED MULBERRY TREE; 2-ARYLBENZOFURAN DERIVATIVES; CUDRANIA-TRICUSPIDATA; DISEASED MULBERRY; ALPHA-GLUCOSIDASE; MORACEAE PLANTS; FLAVONOIDS; PRENYLFLAVONOIDS; PHYTOALEXINS; COMPONENTS;

D O I：

10.1016/j.bmcl.2016.04.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Detailed phytochemical investigation from the root bark of Morus alba resulted in the isolation of eleven new compounds, including seven 2-arylbenzofuran derivatives (morusalfurans A-G), three flavonoids (morusalnols A-C), and one geranylated stilbene (morusibene A), as well as 22 known compounds. The structures of the identified compounds were elucidated based on a comprehensive analysis of spectroscopic data and Mosher's method. Compounds 2, 3, 6-8, 11, 23, 24, and 29 showed potent inhibition of PL in comparison with the positive control treatment (orlistat, IC50 = 0.012 mu M), with IC50 values ranging from 0.09 to 0.92 mu M. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：2788 / 2794

页数：7

共 36 条

[1] Geranylated flavanones from the secretion on the surface of the immature fruits of Paulownia tomentosa [J].